TDR Targets

Basic information

Technical information

TDR Targets ID: 1463480
Name: furan-2-yl-[4-[1-[1-(furan-2-ylmethyl)tetrazo l-5-yl]butyl]piperazin-1-yl]methanone
MW: 384.432 | Formula: C19H24N6O3
H donors: 0 H acceptors: 4 LogP: 1.75 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(c1nnnn1Cc1ccco1)N1CCN(CC1)C(=O)c1ccco1
InChi: 1S/C19H24N6O3/c1-2-5-16(18-20-21-22-25(18)14-15-6-3-12-27-15)23-8-10-24(11-9-23)19(26)17-7-4-13-28-17/h3-4,6-7,12-13,16H,2,5,8-11,14H2,1H3
InChiKey: NINRCLFICVMDJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-furyl-[4-[1-[1-(2-furylmethyl)tetrazol-5-yl]butyl]piperazin-1-yl]methanone
2-furyl-[4-[1-[1-(2-furylmethyl)-5-tetrazolyl]butyl]-1-piperazinyl]methanone
furan-2-yl-[4-[1-[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]butyl]piperazin-1-yl]methanone
ASN 05557291

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.011	1	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.011	1	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.4122	0.3654
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0738	0.0738
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.4122	0.3654
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Schistosoma mansoni	hypothetical protein	0.004	0.2559	0.2326
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.4503	0.4331
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0738	0.0738
Entamoeba histolytica	hypothetical protein	0.0042	0.2793	0.2219
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.011	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.4503	0.4331
Schistosoma mansoni	hypothetical protein	0.0042	0.2793	0.2568
Entamoeba histolytica	serine/threonine protein kinase, putative	0.011	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.2793	0.2568
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0738	0.0448
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.4503	0.4331
Trypanosoma cruzi	polo-like protein kinase, putative	0.011	1	1
Entamoeba histolytica	hypothetical protein	0.0042	0.2793	0.2219
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0738	0.0448
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0738	0.0448
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0738	0.0448
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0738	0.0448
Trypanosoma brucei	polo-like protein kinase	0.011	1	1
Trypanosoma brucei	unspecified product	0.0023	0.0738	0.0738
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0738	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0738	0.0738
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.011	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Brugia malayi	DnaJ domain containing protein	0.0072	0.5908	0.578
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0738	0.0448
Entamoeba histolytica	hypothetical protein	0.0042	0.2793	0.2219
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0738	0.0448
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Entamoeba histolytica	hypothetical protein	0.0042	0.2793	0.2219
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.2793	0.2568
Schistosoma mansoni	kinase	0.0056	0.4276	0.4096
Giardia lamblia	Kinase, PLK	0.011	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.2559	0.2326
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0738	0.0448
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0738	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.2559	0.2326
Schistosoma mansoni	serine/threonine protein kinase	0.011	1	1
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0738	0.0448
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0738	0.5
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0738	0.0448
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0072	0.5908	0.5582
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Schistosoma mansoni	hypothetical protein	0.0072	0.5908	0.578
Trypanosoma cruzi	polo-like protein kinase, putative	0.011	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.4503	0.4331
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0738	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0738	0.0738
Echinococcus granulosus	dna polymerase eta	0.0023	0.0738	0.0448
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.011	1	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0738	0.0448
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.2793	0.2568
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Trichomonas vaginalis	CAMK family protein kinase	0.011	1	1
Echinococcus multilocularis	dnaJ subfamily C 6	0.0072	0.5908	0.578
Echinococcus granulosus	dnaJ subfamily C 6	0.0072	0.5908	0.578
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0738	0.0738
Brugia malayi	hypothetical protein	0.0042	0.2793	0.2568
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0072	0.5908	0.578
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0738	0.0448

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1620876

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1463480