Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arginase 2, mitochondrial | 0.1467 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0073 | 0.0013 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.1381 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0073 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0166 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0073 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0073 | 0.5 |
Trypanosoma cruzi | arginase, putative | 0.0534 | 0.353 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0073 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.006 | 0.36 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0073 | 0.0206 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0073 | 0.0073 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0073 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1467 | 1 | 1 |
Trypanosoma cruzi | arginase, putative | 0.0534 | 0.353 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Leishmania major | agmatinase-like protein | 0.0534 | 0.353 | 0.353 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0073 | 0.4381 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0073 | 0.4381 |
Trypanosoma brucei | agmatinase, putative | 0.0534 | 0.353 | 1 |
Trypanosoma cruzi | agmatinase, putative | 0.0534 | 0.353 | 1 |
Echinococcus multilocularis | 0.1467 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0073 | 0.4381 |
Trypanosoma cruzi | agmatinase, putative | 0.0534 | 0.353 | 1 |
Trichomonas vaginalis | Arginase, putative | 0.1467 | 1 | 1 |
Entamoeba histolytica | Arginase, putative | 0.1467 | 1 | 0.5 |
Echinococcus granulosus | arginase 2 mitochondrial | 0.1467 | 1 | 1 |
Plasmodium vivax | arginase, putative | 0.1467 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0073 | 0.5 |
Plasmodium falciparum | arginase | 0.1467 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0166 | 1 |
Onchocerca volvulus | 0.0035 | 0.0073 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0166 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0073 | 0.0013 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.4381 |
Schistosoma mansoni | arginase | 0.1467 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.006 | 0.36 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0073 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0073 | 0.0206 |
Onchocerca volvulus | 0.0035 | 0.0073 | 0.5 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0073 | 0.4381 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1467 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0073 | 0.4381 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0166 | 1 |
Onchocerca volvulus | 0.0035 | 0.0073 | 0.5 | |
Leishmania major | arginase | 0.1467 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0073 | 0.4381 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0073 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.