Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0641 | 0.5 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0641 | 0.5 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0641 | 0.5 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0641 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Effect on cellular respiration in human T47D cells assessed as increase in oxygen consumption at 1 uM | ChEMBL. | 20929261 |
IC50 (ADMET) | > 20 uM | Cytotoxicity against human T47D cells | ChEMBL. | 20929261 |
Inhibition (functional) | = 50 % | Effect on cellular respiration in human T47D cells assessed as decrease in oxygen consumption at 10 uM | ChEMBL. | 20929261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.