Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NPC1-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.029 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.029 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0243 | 0.7403 | 0.7293 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.029 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.3274 | 0.3274 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.029 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0405 | 0.0405 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0243 | 0.7403 | 0.7293 |
Brugia malayi | Trypsin-like protease protein 5 | 0.029 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0243 | 0.7403 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0243 | 0.7403 | 0.7403 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.029 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.3274 | 0.3274 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.029 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.029 | 1 | 1 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.7403 | 0.7293 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0405 | 0.0405 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.029 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.029 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0405 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0243 | 0.7403 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0243 | 0.7403 | 0.5 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Brugia malayi | Trypsin family protein | 0.029 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.7403 | 0.7264 |
Brugia malayi | Kringle domain containing protein | 0.0243 | 0.7403 | 0.7293 |
Mycobacterium ulcerans | hypothetical protein | 0.029 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0243 | 0.7403 | 0.7403 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.029 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0243 | 0.7403 | 0.5 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Echinococcus multilocularis | enteropeptidase | 0.029 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.029 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.029 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.029 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0243 | 0.7403 | 0.5 |
Onchocerca volvulus | 0.029 | 1 | 1 | |
Echinococcus granulosus | Mastin | 0.029 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.5 uM | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human NCP1L1 expressed in HEK 293 | ChEMBL. | 21030254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.