Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NPC1-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0203 | 0.2123 | 0.75 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Toxoplasma gondii | kringle domain-containing protein | 0.0232 | 0.2535 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.2123 |
Brugia malayi | Trypsin family protein | 0.0203 | 0.2123 | 0.75 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0232 | 0.2535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0203 | 0.2123 | 0.1455 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0203 | 0.2123 | 0.75 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0203 | 0.2123 | 0.75 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0887 | 0.3335 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Mycobacterium ulcerans | hypothetical protein | 0.0203 | 0.2123 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0782 | 0.0782 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.2535 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0742 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Onchocerca volvulus | 0.0232 | 0.2535 | 1 | |
Echinococcus multilocularis | enteropeptidase | 0.0203 | 0.2123 | 0.2123 |
Brugia malayi | Protein kinase domain containing protein | 0.0232 | 0.2535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2535 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.2535 | 0.1784 |
Brugia malayi | Trypsin family protein | 0.0203 | 0.2123 | 0.75 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0203 | 0.2123 | 0.1455 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0232 | 0.2535 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0203 | 0.2123 | 0.1455 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2123 | 0.1331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Loa Loa (eye worm) | trypsin family protein | 0.0203 | 0.2123 | 0.8334 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.2766 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0203 | 0.2123 | 0.2123 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0887 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus multilocularis | Mastin | 0.0203 | 0.2123 | 0.2123 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Brugia malayi | Kringle domain containing protein | 0.0232 | 0.2535 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0887 | 0.0114 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0203 | 0.2123 | 0.2123 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0232 | 0.2535 | 0.1902 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0232 | 0.2535 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2123 | 0.1331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.1633 | 0.1633 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.2535 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2123 | 0.8334 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus granulosus | enteropeptidase | 0.0203 | 0.2123 | 0.1455 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0887 | 0.0887 |
Brugia malayi | hypothetical protein | 0.0203 | 0.2123 | 0.75 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0232 | 0.2535 | 0.2535 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0203 | 0.2123 | 0.2123 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0203 | 0.2123 | 0.1455 |
Echinococcus granulosus | Mastin | 0.0203 | 0.2123 | 0.1455 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.1633 | 0.0924 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Brugia malayi | Trypsin family protein | 0.0203 | 0.2123 | 0.75 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0203 | 0.2123 | 0.1331 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0742 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0203 | 0.2123 | 0.1331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 uM | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human NCP1L1 expressed in HEK 293 | ChEMBL. | 21030254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.