Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.064 | 0.0664 | 0.061 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.064 | 0.0664 | 0.0809 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0308 | 0.0057 | 0.0865 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.064 | 0.0664 | 0.0809 |
Onchocerca volvulus | 0.0308 | 0.0057 | 0.0073 | |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.4405 | 0.7554 | 0.754 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.064 | 0.0664 | 0.0809 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.064 | 0.0664 | 0.0843 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0783 | 0.0926 | 0.0873 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.5741 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.064 | 0.0664 | 0.061 |
Trypanosoma cruzi | prolyl endopeptidase | 0.064 | 0.0664 | 0.0809 |
Brugia malayi | prolyl oligopeptidase family protein | 0.4578 | 0.7871 | 1 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.064 | 0.0664 | 0.061 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.064 | 0.0664 | 0.0776 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.064 | 0.0664 | 0.1377 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.064 | 0.0664 | 0.0809 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0308 | 0.0057 | 0.0865 |
Plasmodium falciparum | peptidase, putative | 0.064 | 0.0664 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.064 | 0.0664 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.4405 | 0.7554 | 0.754 |
Plasmodium vivax | hypothetical protein, conserved | 0.064 | 0.0664 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0308 | 0.0057 | 0.0865 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.064 | 0.0664 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.4405 | 0.7554 | 0.9595 |
Brugia malayi | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 0.0776 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.064 | 0.0664 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.4405 | 0.7554 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 0.0776 |
Entamoeba histolytica | hypothetical protein, conserved | 0.064 | 0.0664 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.4578 | 0.7871 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0783 | 0.0926 | 0.0873 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2331 | 0.3758 | 0.4737 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.4405 | 0.7554 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.4405 | 0.7554 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.064 | 0.0664 | 0.061 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.4578 | 0.7871 | 0.7859 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Trichomonas vaginalis | conserved hypothetical protein | 0.064 | 0.0664 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Brugia malayi | hypothetical protein | 0.2074 | 0.3289 | 0.4135 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Echinococcus multilocularis | prolyl endopeptidase | 0.064 | 0.0664 | 0.061 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0783 | 0.0926 | 0.0873 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.064 | 0.0664 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.2074 | 0.3289 | 0.4135 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.064 | 0.0664 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.064 | 0.0664 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.4405 | 0.7554 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.2714 | 0.446 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.064 | 0.0664 | 1 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0308 | 0.0057 | 0.0865 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0308 | 0.0057 | 0.0865 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.4578 | 0.7871 | 0.7859 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.064 | 0.0664 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.064 | 0.0664 | 0.061 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.064 | 0.0664 | 0.061 |
Toxoplasma gondii | prolyl endopeptidase | 0.064 | 0.0664 | 0.1377 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.064 | 0.0664 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.4578 | 0.7871 | 1 |
Toxoplasma gondii | hypothetical protein | 0.064 | 0.0664 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.0664 | 0.0776 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.064 | 0.0664 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.064 | 0.0664 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.5741 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.4405 | 0.7554 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.4578 | 0.7871 | 0.7859 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.0664 | 0.0776 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0308 | 0.0057 | 0.0865 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.064 | 0.0664 | 0.0776 |
Trypanosoma cruzi | oligopeptidase b | 0.064 | 0.0664 | 0.0809 |
Trypanosoma cruzi | oligopeptidase b | 0.064 | 0.0664 | 0.0809 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.4405 | 0.7554 | 0.754 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by broth microdilution assay | ChEMBL. | 21130651 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans MTCC-183 after 48 hrs by broth microdilution assay | ChEMBL. | 21130651 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans isolate CDRI after 48 hrs by broth microdilution assay | ChEMBL. | 21130651 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans NCIM-3557 after 48 hrs by broth microdilution assay | ChEMBL. | 21130651 |
MIC (functional) | > 200 ug ml-1 | Antitrichomonas activity against Trichomonas vaginalis after 48 hrs by trypan blue exclusion assay | ChEMBL. | 21130651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.