Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | References | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | References | |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0285 | 0.2055 | 0.2108 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.1745 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.006 | 0.0169 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0794 | 0.4338 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.0572 | 0.0536 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.0572 | 0.0536 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0285 | 0.2055 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.0572 | 0.2134 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0794 | 0.4338 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0794 | 0.4338 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.1745 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.1745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0794 | 0.4338 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0794 | 0.3966 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.1745 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0344 | 0.2553 | 0.2636 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.1745 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0066 | 0.0831 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.1745 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0066 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0794 | 0.4338 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.0572 | 0.0536 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.1745 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 1 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0066 | 0.0831 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.1745 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0794 | 0.4338 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0794 | 0.3966 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0794 | 0.3966 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0794 | 0.4338 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0794 | 0.3966 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0066 | 0.0378 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.0672 | 0.2667 |
Onchocerca volvulus | 0.0247 | 0.1735 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.1745 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0794 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0794 | 0.4338 |
Onchocerca volvulus | Putative sulfate transporter | 0.0247 | 0.1735 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0794 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.0572 | 0.0536 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.0672 | 0.0643 |
Mycobacterium ulcerans | carbonic anhydrase | 0.006 | 0.0169 | 0.0169 |
Leishmania major | carbonic anhydrase family protein, putative | 0.006 | 0.0169 | 0.0615 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.1745 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1175 | 0.9502 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0794 | 0.3966 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.1745 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.0672 | 0.0643 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0066 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0066 | 0.0378 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.0572 | 0.0536 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.0572 | 0.0536 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 1 | 0.5 |
Chlamydia trachomatis | sulfate transporter | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.0672 | 0.0643 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0066 | 0.0831 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0794 | 0.4338 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.1745 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6 nM | Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 49.1 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 70.3 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 73.3 nM | Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 89.2 nM | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 3310 nM | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 3310 nM | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.