Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0507 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0421 | 0.0421 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.03 | 0.03 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0421 | 0.151 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0421 | 0.0421 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0171 | 0.2791 | 0.2791 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2791 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0507 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0507 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.004 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0192 | 0.0192 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.193 | 0.193 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0171 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.004 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.004 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.004 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.013 | 0.193 | 0.193 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0421 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0421 | 0.0421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0421 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0171 | 0.2791 | 0.2791 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0421 | 1 |
Plasmodium falciparum | peptidase, putative | 0.004 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0507 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0507 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0171 | 0.2791 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0192 | 0.0192 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.004 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0421 | 0.0421 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2791 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0421 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0192 | 0.0192 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0171 | 0.2791 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.03 | 0.03 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0171 | 0.2791 | 0.2791 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0171 | 0.2791 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0421 | 0.151 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100900 nM | Inhibition of Sprague-Dawley rat imidazoline I1 receptor | ChEMBL. | 21159515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.