Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.05 | 0.4658 | 0.4658 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0609 | 0.6436 | 0.6436 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0609 | 0.6436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.6436 | 0.6069 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0271 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0353 | 0.2274 | 0.3533 |
Brugia malayi | brahma associated protein 60 kDa | 0.0353 | 0.2274 | 0.2274 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0828 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0376 | 0.2645 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0353 | 0.2274 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Schistosoma mansoni | brg-1 associated factor | 0.0353 | 0.2274 | 0.2274 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0376 | 0.2645 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0353 | 0.2274 | 0.2274 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0353 | 0.2274 | 0.2274 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0381 | 0.2733 | 0.6179 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.05 | 0.4658 | 0.7237 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0353 | 0.2274 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0353 | 0.2274 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0485 | 0.4423 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0353 | 0.2274 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0381 | 0.2733 | 0.6179 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.1477 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.05 | 0.4658 | 0.4107 |
Onchocerca volvulus | 0.0353 | 0.2274 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Leishmania major | hypothetical protein, conserved | 0.0272 | 0.0955 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0353 | 0.2274 | 0.3533 |
Loa Loa (eye worm) | brahma associated protein | 0.0353 | 0.2274 | 0.1477 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0609 | 0.6436 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0271 | 0.0935 | 0.9796 |
Echinococcus granulosus | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.05 | 0.4658 | 0.7237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0353 | 0.2274 | 0.5142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.