Detailed information for compound 1467969

Basic information

Technical information
  • TDR Targets ID: 1467969
  • Name: N-cyclopentyl-2-(1H-indol-3-yl)-2-oxoacetamid e
  • MW: 256.3 | Formula: C15H16N2O2
  • H donors: 2 H acceptors: 2 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)c1c[nH]c2c1cccc2)NC1CCCC1
  • InChi: 1S/C15H16N2O2/c18-14(15(19)17-10-5-1-2-6-10)12-9-16-13-8-4-3-7-11(12)13/h3-4,7-10,16H,1-2,5-6H2,(H,17,19)
  • InChiKey: TWMVZOXYFHJJNW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-cyclopentyl-2-(1H-indol-3-yl)-2-oxo-acetamide
  • N-cyclopentyl-2-(1H-indol-3-yl)-2-keto-acetamide
  • N-cyclopentyl-2-(1H-indol-3-yl)-2-oxo-ethanamide
  • ZINC04163118

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Brugia malayi ecdysone receptor 0.0006 0.3839 0.382
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 1 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.9698 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.9698 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 1 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.9698 0.5
Brugia malayi hypothetical protein 0.0006 0.3839 0.382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 1 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.9698 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B 0.0002 0.003 0.003
Brugia malayi nuclear receptor RXR 0.0006 0.3839 0.382
Schistosoma mansoni RAR-like nuclear receptor 0.0012 1 1
Echinococcus multilocularis heat shock protein 70b 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 related 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0002 0.003 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.3839 0.382
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.9698 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Brugia malayi hypothetical protein 0.0012 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0006 0.4498 0.4482
Treponema pallidum DNA ligase (lig) 0.0012 0.9698 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 1 1
Leishmania major heat shock protein 70-related protein 0.0002 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.4498 0.4482
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 1 1
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.9698 1
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.3839 0.3839
Brugia malayi nuclear receptor NHR-67 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 1 1
Brugia malayi DKFZp564C0469 protein 0.0012 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Chlamydia trachomatis DNA ligase 0.0012 0.9698 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.4498 0.4482
Onchocerca volvulus 0.0006 0.3839 0.382
Leishmania major heat-shock protein hsp70, putative 0.0002 0.003 0.5
Loa Loa (eye worm) DR-78 0.0006 0.3839 0.382
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Leishmania major glucose-regulated protein 78, putative 0.0002 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.4498 0.4482
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.3839 0.382
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 1 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.9698 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.3839 0.382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 1 1
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.9698 0.5
Echinococcus multilocularis heat shock protein 70 related 0.0002 0.003 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.4498 0.4482
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.3839 0.382
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.9698 1
Echinococcus multilocularis nibrin 0.0012 0.9698 0.9698
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 1 1
Onchocerca volvulus 0.0012 0.9698 0.9697
Echinococcus multilocularis heat shock protein 70 related 0.0002 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.9698 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 1 1
Entamoeba histolytica hypothetical protein 0.0012 0.9698 1
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0002 0.003 0.003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.3839 0.382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Schistosoma mansoni coup transcription factor 0.0012 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 1 1
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.9698 0.9697
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Brugia malayi Nuclear hormone receptor-like 1 0.0012 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.4498 0.4482
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.3839 0.382
Echinococcus multilocularis 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.9698 1
Leishmania major heat-shock protein hsp70, putative 0.0002 0.003 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Echinococcus multilocularis heat shock kda protein 0.0002 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Echinococcus multilocularis 0.0002 0.003 0.003
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 0.003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.4498 0.4482
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 1 1
Brugia malayi topoisomerase 0.0012 0.9698 0.9697
Brugia malayi nuclear receptor NHR-88 0.0012 1 1
Brugia malayi tailless protein 0.0006 0.3839 0.382
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 1 1
Echinococcus multilocularis 0.0002 0.003 0.003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.3839 0.382
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.9698 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.9698 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 1 1
Brugia malayi Nuclear hormone receptor E75 0.0006 0.3839 0.382
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.9698 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.9698 1
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus multilocularis Heat Shock protein family member (hsp 3) 0.0002 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.3839 0.382
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 1 1
Brugia malayi hypothetical protein 0.0006 0.4498 0.4482
Schistosoma mansoni thyroid hormone receptor 0.0012 1 1
Echinococcus granulosus nibrin 0.0012 0.9698 0.9697
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 1 1
Schistosoma mansoni thyroid hormone receptor 0.0012 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.3839 0.3839
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.4498 0.4482
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.9698 0.9697
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.9698 1
Onchocerca volvulus 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.4498 0.4482
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.9698 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.3839 0.382
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.3839 0.3839
Schistosoma mansoni retinoic acid receptor RXR 0.0012 1 1
Schistosoma mansoni nuclear hormone receptor 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0012 0.9698 0.9697
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.4498 0.4482
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Schistosoma mansoni topbp1 0.0012 0.9698 0.9697
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 1 1
Brugia malayi steroid hormone receptor 0.0012 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 1 1
Brugia malayi hypothetical protein 0.0012 0.9698 0.9697
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.3839 0.3839
Echinococcus multilocularis heat shock 70 kDa protein 1 0.0002 0.003 0.003
Giardia lamblia Replication factor C, subunit 1 0.0012 0.9698 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 0.003 0.003
Brugia malayi nuclear receptor RXR 0.0006 0.4498 0.4482
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.4498 0.4482
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.3839 0.382
Brugia malayi Steroid receptor seven-up type 2 0.0012 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.3839 0.3839
Brugia malayi nuclear hormone receptor 0.0012 1 1
Onchocerca volvulus 0.0012 1 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.9698 0.9697
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.9698 1
Schistosoma mansoni nuclear receptor 0.0006 0.3839 0.382
Echinococcus granulosus replication factor c subunit 1 0.0012 0.9698 0.9697
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.9698 1
Echinococcus multilocularis heat shock 70 kda protein 1a 0.0002 0.003 0.003
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.3839 0.382
Brugia malayi Nuclear hormone receptor E75 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Loa Loa (eye worm) steroid hormone receptor 0.0012 1 1
Schistosoma mansoni nuclear hormone receptor 0.0006 0.3839 0.382
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 1 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.9698 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 1 1
Brugia malayi nuclear hormone receptor 0.0006 0.3839 0.382
Brugia malayi hypothetical protein 0.0006 0.3839 0.382
Schistosoma mansoni nuclear hormone receptor 0.0012 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.3839 0.3839
Brugia malayi hypothetical protein 0.0006 0.4498 0.4482
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 0.003 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.4498 0.4498
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.3839 0.382
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.3839 0.382
Brugia malayi conserved hypotetical protein 0.0006 0.3839 0.382
Echinococcus multilocularis heat shock protein 70 0.0002 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.9698 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 1 1
Schistosoma mansoni topbp1 0.0012 0.9698 0.9697
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.9698 1
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.9698 0.9698
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 1 1
Echinococcus multilocularis heat shock protein 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 1 1
Brugia malayi nuclear receptor NHR-88 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.3839 0.382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 1 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.9698 1
Schistosoma mansoni nuclear receptor 0.0006 0.3839 0.382
Schistosoma mansoni DNA ligase IV 0.0012 0.9698 0.9697
Schistosoma mansoni zinc finger protein 0.0006 0.3839 0.382
Loa Loa (eye worm) hypothetical protein 0.0006 0.3839 0.382
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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