Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0213 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1261 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.4013 | 0.4013 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.4013 | 0.4013 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1003 | 0.7536 | 0.7536 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0634 | 0.4013 | 0.4013 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0213 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1261 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0213 | 0 | 0.5 |
Onchocerca volvulus | 0.0587 | 0.357 | 0.8896 | |
Brugia malayi | Trypsin family protein | 0.0634 | 0.4013 | 0.4013 |
Brugia malayi | Carboxylesterase family protein | 0.1261 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1003 | 0.7536 | 0.7536 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0634 | 0.4013 | 0.4013 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1261 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1261 | 1 | 1 |
Onchocerca volvulus | 0.0634 | 0.4013 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0213 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1261 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1261 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0213 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0213 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1261 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 13 nM | Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation | ChEMBL. | 21093272 |
Imax (functional) | = 100 % | Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation relative to SB-271047 | ChEMBL. | 21093272 |
Ki (binding) | = 6.7 nM | Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells | ChEMBL. | 21093272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.