Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.11 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0232 | 0.0334 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0122 | 0.0175 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0232 | 0.0111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0232 | 0.0111 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0774 | 0.695 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0122 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0122 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0456 | 0.3977 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0122 | 0.0175 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0122 | 0.0175 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0122 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0456 | 0.3977 | 0.5722 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0232 | 0.0111 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0232 | 0.0285 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0122 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0122 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0774 | 0.695 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0122 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0232 | 0.0334 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0122 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0456 | 0.3977 | 0.5722 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0122 | 0.0175 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0232 | 0.0111 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0456 | 0.3977 | 0.3902 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0456 | 0.3977 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0122 | 0.0175 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0122 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0122 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0122 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0122 | 0.0175 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0774 | 0.695 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0774 | 0.695 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0774 | 0.695 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0122 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0122 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0456 | 0.3977 | 0.3902 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0122 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3413 | 0.4911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0232 | 0.0285 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0122 | 0.0175 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0122 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0122 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0122 | 0.0175 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0232 | 0.0285 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.0175 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.