TDR Targets

Basic information

Technical information

TDR Targets ID: 147126
Name: 4-[6-(3-chloro-4-fluorophenyl)spiro[2.4]hept- 5-en-5-yl]benzenesulfonamide
MW: 377.86 | Formula: C19H17ClFNO2S
H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1Cl)C1=C(CC2(C1)CC2)c1ccc(cc1)S(=O)(=O)N
InChi: 1S/C19H17ClFNO2S/c20-17-9-13(3-6-18(17)21)16-11-19(7-8-19)10-15(16)12-1-4-14(5-2-12)25(22,23)24/h1-6,9H,7-8,10-11H2,(H2,22,23,24)
InChiKey: PBSAWAMHURBEDJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[6-(3-chloro-4-fluoro-phenyl)spiro[2.4]hept-5-en-5-yl]benzenesulfonamide
4-[6-(3-chloro-4-fluorophenyl)-5-spiro[2.4]hept-5-enyl]benzenesulfonamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	orexin receptor type 2	0.0071	0.0659	0.4008
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0659	0.4008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Onchocerca volvulus		0.0071	0.0659	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0659	0.0908
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0659	0.4008
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0096	0.2962	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0111	0.4302	1
Echinococcus granulosus	hypothetical protein	0.0071	0.0659	0.4008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Echinococcus granulosus	ryanodine receptor 44f	0.0082	0.1645	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	sex peptide receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.0659	0.1495
Brugia malayi	Serotonin receptor	0.0071	0.0659	0.0642
Schistosoma mansoni	opsin-like receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.0659	0.0908
Echinococcus granulosus	fmrfamide receptor	0.0071	0.0659	0.4008
Brugia malayi	larval opioid receptor	0.0071	0.0659	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Leishmania major	hypothetical protein, conserved	0.0065	0.0189	0.5
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0071	0.0659	0.0908
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0071	0.0659	0.0908
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Brugia malayi	Serotonin receptor	0.0071	0.0659	0.0642
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0071	0.0659	0.0908
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.0659	0.1495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	allatostatin A receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0071	0.0659	0.0642
Schistosoma mansoni	hypothetical protein	0.0071	0.0659	0.0908
Brugia malayi	G-protein coupled receptor	0.0071	0.0659	0.0642
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0659	0.0908
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.0659	0.4008
Brugia malayi	Melatonin receptor type 1A	0.0071	0.0659	0.0642
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.0659	0.4008
Echinococcus granulosus	g-protein coupled receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	neuropeptide s receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Onchocerca volvulus		0.0071	0.0659	1
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus multilocularis	allatostatin A receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0071	0.0659	0.4008
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0071	0.0659	0.4008
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	G protein coupled receptor 139	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1645	0.3797
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	peroxidasin	0.0063	0.0019	0.0115
Schistosoma mansoni	amine GPCR	0.0071	0.0659	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Brugia malayi	RE15519p	0.0071	0.0659	0.0642
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Schistosoma mansoni	adenoreceptor	0.0071	0.0659	0.0908
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.0659	0.4008
Brugia malayi	Dopamine receptor protein 2	0.0071	0.0659	0.0642
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	sex peptide receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Schistosoma mansoni	growth hormone secretagogue receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Onchocerca volvulus		0.0071	0.0659	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	amine GPCR	0.0071	0.0659	0.0908
Schistosoma mansoni	hypothetical protein	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Onchocerca volvulus		0.0071	0.0659	1
Brugia malayi	neuropeptide F receptor	0.0071	0.0659	0.0642
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0071	0.0659	0.4008
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0071	0.0659	0.0908
Brugia malayi	Dopamine receptor	0.0071	0.0659	0.0642
Echinococcus multilocularis	orexin receptor type 2	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0109	0.4113	0.9559
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0659	0.4008
Echinococcus granulosus	7tm_1 domain containing protein	0.0071	0.0659	0.4008
Schistosoma mansoni	histamine h1 receptor	0.0071	0.0659	0.0908
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	somatostatin receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0071	0.0659	0.4008
Schistosoma mansoni	opsin-like receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	amine GPCR	0.0071	0.0659	0.0908
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0071	0.0659	0.0642
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	G protein coupled receptor 139	0.0071	0.0659	0.4008
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0071	0.0659	0.1495
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2657	0.6159
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	dro:myosuppressin receptor	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Schistosoma mansoni	amine GPCR	0.0071	0.0659	0.0908
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.0659	0.4008
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0142	0.7075	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0071	0.0659	0.4008
Brugia malayi	GnHR receptor homolog	0.0071	0.0659	0.0642
Brugia malayi	G-protein coupled receptor	0.0071	0.0659	0.0642
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0659	0.4008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	opsin-like receptor	0.0071	0.0659	0.0908
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0071	0.0659	0.0908
Brugia malayi	sulfakinin receptor protein	0.0071	0.0659	0.0642
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.0659	0.4008
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0659	0.0908
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0071	0.0659	0.1495
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.0659	0.4008
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0071	0.0659	1
Brugia malayi	neuropeptide F receptor	0.0071	0.0659	0.0642
Onchocerca volvulus		0.0071	0.0659	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0093	0.2657	0.3739
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	g-protein coupled receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	dro:myosuppressin receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0071	0.0659	0.4008
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0071	0.0659	0.0642
Echinococcus multilocularis	serotonin receptor	0.0071	0.0659	0.4008
Brugia malayi	G protein-coupled receptor F59B2.13	0.0071	0.0659	0.0642
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	neuropeptide receptor	0.0071	0.0659	0.4008
Brugia malayi	ORL1-like opioid receptor	0.0071	0.0659	0.0642
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.0659	0.4008
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	neuropeptide f receptor 76f	0.0071	0.0659	0.0908
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.0659	0.0908
Brugia malayi	putative neuropeptide receptor	0.0071	0.0659	0.0642
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0659	0.0908
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.0659	0.0908
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0071	0.0659	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Brugia malayi	AKH receptor	0.0071	0.0659	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0071	0.0659	0.0642
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0071	0.0659	0.0908
Echinococcus granulosus	serotonin receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	melatonin receptor type 1A	0.0071	0.0659	0.1495
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	hypothetical protein	0.0071	0.0659	0.0908
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0071	0.0659	1
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus granulosus	neuropeptide s receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0659	0.0908
Schistosoma mansoni	hypothetical protein	0.0071	0.0659	0.0908
Brugia malayi	Dopamine receptor protein 1	0.0071	0.0659	0.0642
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	serotonin receptor	0.0071	0.0659	0.4008
Echinococcus multilocularis	somatostatin receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Schistosoma mansoni	myosin xvIII	0.0071	0.0659	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0071	0.0659	0.4008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0659	0.4008
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0071	0.0659	0.1495
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0114	0.457	0.456
Onchocerca volvulus		0.0071	0.0659	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0071	0.0659	0.0642
Brugia malayi	G protein-coupled receptor	0.0071	0.0659	0.0642
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0071	0.0659	0.4008
Echinococcus granulosus	7TM GPCR rhodopsin	0.0071	0.0659	0.4008
Brugia malayi	follicle stimulating hormone receptor	0.0071	0.0659	0.0642
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0071	0.0659	0.0642
Echinococcus granulosus	neuropeptide receptor A26	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	neuropeptide FF receptor 2	0.0071	0.0659	0.4008
Echinococcus granulosus	neuropeptide receptor	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0096	0.2962	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	ryanodine receptor 44f	0.0082	0.1645	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Schistosoma mansoni	amine GPCR	0.0071	0.0659	0.0908
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0659	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0071	0.0659	0.4008
Onchocerca volvulus		0.0071	0.0659	1
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.0659	0.4008
Brugia malayi	hypothetical protein	0.0071	0.0659	0.0642
Onchocerca volvulus		0.0071	0.0659	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.0659	0.4008
Schistosoma mansoni	ryanodine receptor related	0.0114	0.457	0.6451
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0659	0.4008
Echinococcus multilocularis	peroxidasin	0.0063	0.0019	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0659	0.1495
Loa Loa (eye worm)	TYRA-2 protein	0.0071	0.0659	0.1495

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.82	Inhibition of human Prostaglandin G/H synthase 2	ChEMBL.	11563921
IC50 (binding)	= 0.0015 uM	Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).	ChEMBL.	8568815
IC50 (binding)	= 0.0015 uM	Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).	ChEMBL.	8568815
IC50 (binding)	= 0.31 uM	Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).	ChEMBL.	8568815
IC50 (binding)	= 0.31 uM	Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).	ChEMBL.	8568815
Log IC50 (binding)	= 8.82	Inhibition of human Prostaglandin G/H synthase 2	ChEMBL.	11563921

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL312822
PubChem: 10667341

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 147126