Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.0453 | 0.0414 |
Onchocerca volvulus | 0.2653 | 1 | 0.5 | |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.2653 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0445 | 0.1617 | 0.1584 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.0673 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.1083 | 0.1047 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0141 | 0.0462 | 0.0384 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.0673 | 0.0635 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.0673 | 0.0635 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0141 | 0.0462 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.2653 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.0673 | 0.0673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.029 | 0.1027 | 0.0954 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Brugia malayi | RNA binding protein | 0.0196 | 0.0673 | 0.0673 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.1577 | 0.5916 | 0.5882 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.1083 | 0.101 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.029 | 0.1027 | 0.0991 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0304 | 0.1083 | 0.1083 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0141 | 0.0462 | 0.0462 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.0673 | 0.0597 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0462 | 0.0384 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.004 | 0.1053 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0445 | 0.1617 | 0.1617 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0462 | 0.0424 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.004 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0081 | 0.0041 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.004 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0141 | 0.0462 | 0.0384 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.029 | 0.1027 | 0.0954 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.1076 | 0.4012 | 0.3963 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.004 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0141 | 0.0462 | 0.0462 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.2653 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.004 | 0.0081 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.029 | 0.1027 | 0.0954 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.029 | 0.1027 | 0.0954 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.029 | 0.1027 | 0.0954 |
Echinococcus multilocularis | GPCR, family 2 | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.004 | 0.1053 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0141 | 0.0462 | 0.0384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.0673 | 0.0597 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0141 | 0.0462 | 0.0424 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.0453 | 0.0414 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.0673 | 0.0597 |
Brugia malayi | hypothetical protein | 0.003 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1617 | 0.1584 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.029 | 0.1027 | 0.1027 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0445 | 0.1617 | 0.1617 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.0081 | 0.0081 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.0673 | 0.0673 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Estrogenic potency (functional) | = 17 | Evaluation of oral estrogenic activity by using immature female rats ovariectomized at 21 days of age. | ChEMBL. | 3560158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.