Detailed information for compound 1472323

Basic information

Technical information
  • TDR Targets ID: 1472323
  • Name: 3-(3,4-dimethoxyphenyl)-6,7-dimethoxyisoquino line
  • MW: 325.358 | Formula: C19H19NO4
  • H donors: 0 H acceptors: 1 LogP: 3.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)c1ncc2c(c1)cc(c(c2)OC)OC
  • InChi: 1S/C19H19NO4/c1-21-16-6-5-12(8-17(16)22-2)15-7-13-9-18(23-3)19(24-4)10-14(13)11-20-15/h5-11H,1-4H3
  • InChiKey: LLYQTYHOTHOUQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-isoquinoline
  • 69504-70-7
  • Oprea1_586136
  • ZINC00350310
  • AE-907/30535051
  • NSC290081
  • STOCK1N-07853

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Loa Loa (eye worm) matrixin family protein 0.0741 0.4843 0.7805
Schistosoma mansoni heat shock protein 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0681 0.4131 0.5
Treponema pallidum heat shock protein 90 0.0681 0.4131 0.5
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0351 0.0195 0.0403
Trichomonas vaginalis heat shock protein, putative 0.0855 0.6204 1
Echinococcus granulosus heat shock protein 90 0.0681 0.4131 0.4014
Onchocerca volvulus 0.0433 0.1181 0.2439
Trypanosoma brucei Heat shock protein 83, putative 0.0855 0.6204 1
Entamoeba histolytica heat shock protein 90, putative 0.0855 0.6204 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0741 0.4843 1
Loa Loa (eye worm) heat shock protein 90 0.0855 0.6204 1
Brugia malayi Hemopexin family protein 0.0433 0.1181 0.1904
Trypanosoma cruzi heat shock protein 90, putative 0.0681 0.4131 0.655
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Plasmodium falciparum heat shock protein 90 0.0855 0.6204 1
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Plasmodium vivax heat shock protein 86, putative 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Schistosoma mansoni heat shock protein 0.0351 0.0195 0.0315
Trypanosoma cruzi heat shock protein 85, putative 0.0855 0.6204 1
Trichomonas vaginalis heat shock protein, putative 0.0681 0.4131 0.655
Entamoeba histolytica heat shock protein 90, putative 0.0855 0.6204 1
Trypanosoma brucei heat shock protein 90, putative 0.0855 0.6204 1
Echinococcus granulosus heat shock protein 0.0855 0.6204 0.6129
Loa Loa (eye worm) endoplasmin 0.0855 0.6204 1
Toxoplasma gondii heat shock protein 90, putative 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Mycobacterium ulcerans heat shock protein 90 0.0681 0.4131 1
Trypanosoma brucei heat shock protein 90, putative 0.0855 0.6204 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0681 0.4131 0.655
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Trichomonas vaginalis heat shock protein, putative 0.0681 0.4131 0.655
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0607 0.3253 0.5244
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0512 0.212 0.3417
Brugia malayi Matrixin family protein 0.0767 0.5157 0.8313
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Trichomonas vaginalis endoplasmin, putative 0.0525 0.2269 0.345
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0681 0.4131 1
Brugia malayi heat shock protein 90 0.0855 0.6204 1
Trypanosoma cruzi heat shock protein 90, putative 0.0855 0.6204 1
Echinococcus granulosus endoplasmin 0.0681 0.4131 0.4014
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Trypanosoma cruzi heat shock protein 90, putative 0.0505 0.2033 0.3058
Giardia lamblia Heat shock protein HSP 90-alpha 0.0855 0.6204 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1174 1 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0681 0.4131 0.4014
Schistosoma mansoni endoplasmin 0.0855 0.6204 1
Trypanosoma cruzi heat shock protein 85, putative 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Trypanosoma cruzi heat shock protein 85, putative 0.0681 0.4131 0.655
Echinococcus granulosus heat shock protein 90 0.0855 0.6204 0.6129
Trypanosoma cruzi heat shock protein 85, putative 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Echinococcus multilocularis heat shock protein 0.0855 0.6204 0.6129
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0407 0.0867 0.1397
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Loa Loa (eye worm) hypothetical protein 0.0407 0.0867 0.1397
Loa Loa (eye worm) heat shock protein 75 0.0351 0.0195 0.0315
Schistosoma mansoni endoplasmin 0.0855 0.6204 1
Onchocerca volvulus Matrilysin homolog 0.0741 0.4843 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Echinococcus multilocularis heat shock protein 90 0.0681 0.4131 0.4014
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Toxoplasma gondii heat shock protein HSP90 0.0855 0.6204 1
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Echinococcus multilocularis endoplasmin 0.0681 0.4131 0.4014
Trichomonas vaginalis heat shock protein, putative 0.0681 0.4131 0.655
Schistosoma mansoni heat shock protein 0.0855 0.6204 1
Brugia malayi Hsp90 protein 0.0351 0.0195 0.0315
Trypanosoma brucei heat shock protein, putative 0.0855 0.6204 1
Brugia malayi Angiotensin-converting enzyme family protein 0.0607 0.3253 0.5244
Leishmania major heat shock protein 83-1 0.0855 0.6204 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0681 0.4131 1
Schistosoma mansoni hypothetical protein 0.0433 0.1181 0.1904
Trypanosoma cruzi Heat shock protein 83, putative 0.0855 0.6204 1
Loa Loa (eye worm) matrixin family protein 0.0767 0.5157 0.8313
Plasmodium vivax endoplasmin, putative 0.0855 0.6204 1
Trichomonas vaginalis heat shock protein, putative 0.0525 0.2269 0.345
Echinococcus multilocularis heat shock protein 90 0.0855 0.6204 0.6129
Brugia malayi Endoplasmin precursor 0.0855 0.6204 1
Plasmodium falciparum endoplasmin, putative 0.0525 0.2269 0.345

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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