Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0376 | 0.2645 | 1 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0376 | 0.2645 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0353 | 0.2274 | 0.2274 |
Chlamydia trachomatis | SWIB complex protein | 0.0353 | 0.2274 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0353 | 0.2274 | 0.2274 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0828 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0353 | 0.2274 | 0.3533 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0381 | 0.2733 | 0.6179 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0353 | 0.2274 | 0.2274 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.05 | 0.4658 | 0.7237 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Brugia malayi | brahma associated protein 60 kDa | 0.0353 | 0.2274 | 0.2274 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.2274 | 0.2274 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.05 | 0.4658 | 0.4658 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0609 | 0.6436 | 0.6436 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0609 | 0.6436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0271 | 0.0935 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.6436 | 0.6069 |
Leishmania major | hypothetical protein, conserved | 0.0272 | 0.0955 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0353 | 0.2274 | 0.3533 |
Echinococcus granulosus | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.05 | 0.4658 | 0.4107 |
Onchocerca volvulus | 0.0353 | 0.2274 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.0271 | 0.0935 | 0.1453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0353 | 0.2274 | 0.5142 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.05 | 0.4658 | 0.7237 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0609 | 0.6436 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0353 | 0.2274 | 0.1477 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0353 | 0.2274 | 0.3533 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0271 | 0.0935 | 0.9796 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0485 | 0.4423 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0271 | 0.0935 | 0.0935 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0485 | 0.4423 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0353 | 0.2274 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0353 | 0.2274 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0609 | 0.6436 | 1 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0272 | 0.0955 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0353 | 0.2274 | 0.1477 |
Plasmodium vivax | hypothetical protein, conserved | 0.0353 | 0.2274 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0381 | 0.2733 | 0.6179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.