Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0077 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0077 | 0.2768 | 0.2808 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0077 | 0.2768 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0132 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0077 | 0.2768 | 0.2768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.013 | 0.9857 | 0.9857 |
Schistosoma mansoni | protein kinase | 0.0132 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.9857 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0077 | 0.2768 | 0.2808 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0077 | 0.2768 | 0.2768 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0132 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0077 | 0.2768 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0132 | 1 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0077 | 0.2768 | 0.2768 |
Trichomonas vaginalis | STE family protein kinase | 0.0132 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0132 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0132 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0132 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0132 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0132 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0132 | 1 | 0.5 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0132 | 1 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0132 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.