Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | References | |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | References | |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0435 | 0.1364 | 0.5 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0435 | 0.1364 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0435 | 0.1364 | 0.1356 |
Echinococcus granulosus | caspase 2 | 0.0435 | 0.1364 | 0.1356 |
Trypanosoma brucei | metacaspase MCA2 | 0.0435 | 0.1364 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0435 | 0.1364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1364 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0435 | 0.1364 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 0.7159 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0435 | 0.1364 | 0.1356 |
Echinococcus granulosus | caspase 3 | 0.1191 | 0.6848 | 0.6845 |
Trypanosoma brucei | Metacaspase-4 | 0.0435 | 0.1364 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0285 | 0.0277 | 0.5 |
Plasmodium falciparum | metacaspase-like protein | 0.0435 | 0.1364 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0435 | 0.1364 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0435 | 0.1364 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.1626 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0435 | 0.1364 | 1 |
Leishmania major | metacaspase, putative | 0.0435 | 0.1364 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0435 | 0.1364 | 0.5 |
Trypanosoma brucei | metacaspase | 0.0435 | 0.1364 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0435 | 0.1364 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0344 | 0.0709 | 0.0669 |
Plasmodium vivax | metacaspase 1, putative | 0.0435 | 0.1364 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0435 | 0.1364 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0435 | 0.1364 | 1 |
Echinococcus granulosus | caspase | 0.1626 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0435 | 0.1364 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1175 | 0.6727 | 1 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0435 | 0.1364 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0435 | 0.1364 | 0.1356 |
Echinococcus granulosus | caspase 8 | 0.0435 | 0.1364 | 0.1356 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1626 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1364 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0435 | 0.1364 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0435 | 0.1364 | 1 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0435 | 0.1364 | 0.1356 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0435 | 0.1364 | 1 |
Echinococcus multilocularis | caspase 3 | 0.1191 | 0.6848 | 0.6845 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 0.7159 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.1626 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1234 | 0.7159 | 0.5 |
Echinococcus multilocularis | caspase | 0.1626 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 58.8 nM | Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 64.5 nM | Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 83 nM | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 3725 nM | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 3725 nM | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 4330 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 6380 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.