Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.4487 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0758 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0758 | 0 | 0.5 |
Onchocerca volvulus | 0.0758 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.4487 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4487 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.4487 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4487 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.4487 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0758 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4487 | 1 | 1 |
Onchocerca volvulus | 0.0758 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.4487 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0758 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.4487 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4487 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4487 | 1 | 1 |
Onchocerca volvulus | 0.0758 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0758 | 0 | 0.5 |
Onchocerca volvulus | 0.0758 | 0 | 0.5 | |
Onchocerca volvulus | 0.0758 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.4487 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0758 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.