Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0233 | 0.0533 | 0.0357 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.0537 | 1 |
Echinococcus granulosus | ankyrin repeat protein | 0.016 | 0.0315 | 0.0135 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.016 | 0.0315 | 0.3797 |
Brugia malayi | dihydrofolate reductase family protein | 0.0233 | 0.0533 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.0537 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.0182 | 0.5 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0163 | 0.0325 | 0.0145 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0233 | 0.0533 | 0.0533 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.0537 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0375 | 0.5488 |
Brugia malayi | thymidylate synthase | 0.0116 | 0.0182 | 0.3423 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0233 | 0.0533 | 0.0357 |
Echinococcus multilocularis | ankyrin repeat protein | 0.016 | 0.0315 | 0.0135 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0233 | 0.0533 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0233 | 0.0533 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.0537 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0233 | 0.0533 | 0.139 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0956 | 0.2704 | 0.2568 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0956 | 0.2704 | 0.2704 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.3387 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0234 | 0.0537 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0233 | 0.0533 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0163 | 0.0325 | 0.0145 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0233 | 0.0533 | 0.0357 |
Echinococcus granulosus | kinesin family 1 | 0.0207 | 0.0455 | 0.0278 |
Echinococcus multilocularis | thymidine phosphorylase | 0.3387 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.3387 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0116 | 0.0182 | 0.0182 |
Schistosoma mansoni | dihydrofolate reductase | 0.0233 | 0.0533 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0234 | 0.0537 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0207 | 0.0455 | 0.0278 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0956 | 0.2704 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.