Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Thymidine kinase | 0.0794 | 1 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0407 | 0.1572 | 0.1463 |
Trypanosoma brucei | thymidine kinase | 0.0794 | 1 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0407 | 0.1572 | 0.1463 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0407 | 0.1572 | 1 |
Leishmania major | thymidine kinase, putative | 0.0794 | 1 | 0.5 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0407 | 0.1572 | 0.5 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0407 | 0.1572 | 0.5 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0407 | 0.1572 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0407 | 0.1572 | 0.1463 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0407 | 0.1572 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0482 | 0.3206 | 0.3118 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0482 | 0.3206 | 0.3118 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0407 | 0.1572 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0407 | 0.1572 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0407 | 0.1572 | 0.1463 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0407 | 0.1572 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0794 | 1 | 0.5 |
Brugia malayi | dUTP diphosphatase | 0.0407 | 0.1572 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0482 | 0.3206 | 0.3118 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0794 | 1 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0482 | 0.3206 | 0.3118 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0794 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0794 | 1 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0407 | 0.1572 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0794 | 1 | 1 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0407 | 0.1572 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.