Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | H(+):Cl() exchange transporter 4 | 0.0036 | 0.0064 | 0.0064 |
Treponema pallidum | Mg2+ transport protein (mgtE) | 0.0036 | 0.0064 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.0511 | 1 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0061 | 0.0511 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0064 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0064 | 0.5 |
Schistosoma mansoni | chloride channel protein | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0587 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0064 | 0.5 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.0036 | 0.0064 | 0.5 |
Echinococcus multilocularis | AMPK beta subunit | 0.0061 | 0.0511 | 0.0511 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0036 | 0.0064 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0053 | 0.0371 | 1 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0128 | 0.172 | 0.172 |
Echinococcus granulosus | SNF4:AMP activated protein kinase gamma subunit | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0036 | 0.0064 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | H:Cl exchange transporter 3 | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0064 | 0.5 |
Toxoplasma gondii | CBS family protein | 0.0036 | 0.0064 | 1 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0061 | 0.0511 | 0.0449 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.055 | 0.9345 | 0.9345 |
Echinococcus multilocularis | H(+):Cl() exchange transporter 3 | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | AMPK beta subunit | 0.0061 | 0.0511 | 0.0511 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0061 | 0.0511 | 0.0449 |
Echinococcus multilocularis | SNF4:AMP activated protein kinase gamma subunit | 0.0036 | 0.0064 | 0.0064 |
Chlamydia trachomatis | Mg++ transporter | 0.0036 | 0.0064 | 0.5 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0036 | 0.0064 | 0.5 |
Schistosoma mansoni | chloride channel protein | 0.0036 | 0.0064 | 0.0064 |
Toxoplasma gondii | IMP dehydrogenas | 0.0036 | 0.0064 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0064 | 0.5 |
Toxoplasma gondii | chloride transporter, chloride channel (ClC) family protein | 0.0036 | 0.0064 | 1 |
Echinococcus multilocularis | H(+):Cl() exchange transporter 7 | 0.0036 | 0.0064 | 0.0064 |
Echinococcus granulosus | H:Cl exchange transporter 7 | 0.0036 | 0.0064 | 0.0064 |
Chlamydia trachomatis | GutQ/KpsF family sugar-phosphate isomerase | 0.0036 | 0.0064 | 0.5 |
Toxoplasma gondii | CBS domain-containing protein | 0.0036 | 0.0064 | 1 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0587 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0036 | 0.0064 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0064 | 0.5 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0036 | 0.0064 | 0.5 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | transcriptional regulator | 0.0036 | 0.0064 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0587 | 1 | 1 |
Echinococcus granulosus | H:Cl exchange transporter 4 | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | AMP activated protein kinase gamma regulatory | 0.0036 | 0.0064 | 0.0064 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0061 | 0.0511 | 0.0449 |
Wolbachia endosymbiont of Brugia malayi | Mg/Co/Ni transporter MgtE | 0.0036 | 0.0064 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 0.172 | 0.172 |
Schistosoma mansoni | protein kinase subunit beta | 0.0061 | 0.0511 | 0.0511 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0036 | 0.0064 | 0.0064 |
Toxoplasma gondii | CBS domain-containing protein | 0.0036 | 0.0064 | 1 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0587 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane alanine and leucine rich protein | 0.0036 | 0.0064 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0128 | 0.172 | 0.1667 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0587 | 1 | 1 |
Schistosoma mansoni | chloride channel protein | 0.0036 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Hypoxic response protein 1 Hrp1 | 0.0036 | 0.0064 | 0.5 |
Plasmodium falciparum | protein MAM3, putative | 0.0036 | 0.0064 | 0.5 |
Chlamydia trachomatis | CBS domain-containing protein | 0.0036 | 0.0064 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Mg2+/Co2+ transporter | 0.0036 | 0.0064 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0036 | 0.0064 | 0.5 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0128 | 0.172 | 0.1667 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0061 | 0.0511 | 1 |
Wolbachia endosymbiont of Brugia malayi | hemolysin | 0.0036 | 0.0064 | 0.5 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0061 | 0.0511 | 0.0449 |
Treponema pallidum | hemolysin (tlyC) | 0.0036 | 0.0064 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0128 | 0.172 | 0.172 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0036 | 0.0064 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0036 | 0.0064 | 0.0064 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0036 | 0.0064 | 0.0064 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0061 | 0.0511 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.