TDR Targets

Basic information

Technical information

TDR Targets ID: 1475754
Name: 2-(2-methyloxan-4-yl)-4-phenyl-1,3-thiazole
MW: 259.367 | Formula: C15H17NOS
H donors: 0 H acceptors: 1 LogP: 3.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1OCCC(C1)c1scc(n1)c1ccccc1
InChi: 1S/C15H17NOS/c1-11-9-13(7-8-17-11)15-16-14(10-18-15)12-5-3-2-4-6-12/h2-6,10-11,13H,7-9H2,1H3
InChiKey: BIXHKCSGAFJSKI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-methyltetrahydropyran-4-yl)-4-phenyl-thiazole
2-(2-methyl-4-tetrahydropyranyl)-4-phenylthiazole
Oprea1_802132
STOCK1S-22911

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	5' AMP activated protein kinase subunit beta 1	0.003	0.0236	0.0236
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0116	0.2986	0.2986
Leishmania major	hypothetical protein, conserved	0.0055	0.1052	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Loa Loa (eye worm)	5'-AMP-activated protein kinase	0.0055	0.1052	0.1052
Schistosoma mansoni	protein kinase subunit beta	0.003	0.0236	0.0236
Echinococcus granulosus	AMPK beta subunit	0.0055	0.1052	0.1052
Plasmodium falciparum	serine/threonine protein kinase KIN	0.0022	0	0.5
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0022	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0055	0.1052	0.1052
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Echinococcus granulosus	5' AMP activated protein kinase catalytic	0.0116	0.2986	0.2986
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trypanosoma cruzi	5'-AMP-activated protein kinase subunit beta, putative	0.0055	0.1052	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0336	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trypanosoma cruzi	SNF1-related protein kinase regulatory subunit beta, putative	0.0055	0.1052	1
Onchocerca volvulus	Alicorn homolog	0.0048	0.083	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0116	0.2986	0.2986
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0022	0	0.5
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0336	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0055	0.1052	0.1052
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Echinococcus granulosus	5' AMP activated protein kinase subunit beta 1	0.003	0.0236	0.0236
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Echinococcus multilocularis	AMPK beta subunit	0.0055	0.1052	0.1052
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0336	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Toxoplasma gondii	5'-AMP-activated protein kinase subunit beta-1 family protein, putative	0.0033	0.033	1
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Schistosoma mansoni	protein kinase subunit gamma	0.0336	1	1
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0315	0.9337	0.9337
Brugia malayi	EST embl\|AI107989\|AI107989 comes from the 3' UTR, putative	0.0116	0.2986	0.2986
Loa Loa (eye worm)	loechrig isoform VII	0.0336	1	1
Giardia lamblia	5-AMP-activated protein kinase, beta-1 subunit	0.0055	0.1052	0.1052
Echinococcus multilocularis	5' AMP activated protein kinase catalytic	0.0116	0.2986	0.2986
Schistosoma mansoni	protein kinase subunit beta	0.0055	0.1052	0.1052
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0022	0	0.5
Trypanosoma brucei	5'-AMP-activated protein kinase subunit beta	0.0055	0.1052	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1618933

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1475754