Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | hemolysin (tlyC) | 0.0052 | 0.0232 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.013 | 0.1199 | 0.1199 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0062 | 0.0356 | 0.0126 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0052 | 0.0232 | 0.0232 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0052 | 0.0232 | 0.0232 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0062 | 0.0356 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0052 | 0.0232 | 0.5 |
Chlamydia trachomatis | CBS domain-containing protein | 0.0052 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Hypoxic response protein 1 Hrp1 | 0.0052 | 0.0232 | 0.5 |
Schistosoma mansoni | chloride channel protein | 0.0052 | 0.0232 | 0.0232 |
Plasmodium falciparum | protein MAM3, putative | 0.0052 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0052 | 0.0232 | 0.5 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.013 | 0.1199 | 0.0989 |
Wolbachia endosymbiont of Brugia malayi | hemolysin | 0.0052 | 0.0232 | 0.5 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0062 | 0.0356 | 1 |
Wolbachia endosymbiont of Brugia malayi | Mg2+/Co2+ transporter | 0.0052 | 0.0232 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Mg/Co/Ni transporter MgtE | 0.0052 | 0.0232 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.013 | 0.1199 | 0.1199 |
Schistosoma mansoni | protein kinase subunit beta | 0.0062 | 0.0356 | 0.0356 |
Echinococcus granulosus | AMP activated protein kinase gamma regulatory | 0.0052 | 0.0232 | 0.0232 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0062 | 0.0356 | 0.0126 |
Toxoplasma gondii | CBS domain-containing protein | 0.0052 | 0.0232 | 1 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0838 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane alanine and leucine rich protein | 0.0052 | 0.0232 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.013 | 0.1199 | 0.0989 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0838 | 1 | 1 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0052 | 0.0232 | 0.0232 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0052 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0052 | 0.0232 | 0.5 |
Schistosoma mansoni | AMP-activated protein kinase gamma regulatory subunit | 0.0052 | 0.0232 | 0.0232 |
Chlamydia trachomatis | GutQ/KpsF family sugar-phosphate isomerase | 0.0052 | 0.0232 | 0.5 |
Toxoplasma gondii | CBS domain-containing protein | 0.0052 | 0.0232 | 1 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0838 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0052 | 0.0232 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0232 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0052 | 0.0232 | 0.5 |
Echinococcus granulosus | H:Cl exchange transporter 4 | 0.0052 | 0.0232 | 0.0232 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0838 | 1 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0052 | 0.0232 | 0.0232 |
Mycobacterium ulcerans | transcriptional regulator | 0.0052 | 0.0232 | 0.5 |
Echinococcus multilocularis | H(+):Cl() exchange transporter 7 | 0.0052 | 0.0232 | 0.0232 |
Toxoplasma gondii | chloride transporter, chloride channel (ClC) family protein | 0.0052 | 0.0232 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0052 | 0.0232 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0052 | 0.0232 | 1 |
Echinococcus granulosus | H:Cl exchange transporter 7 | 0.0052 | 0.0232 | 0.0232 |
Echinococcus granulosus | AMPK beta subunit | 0.0062 | 0.0356 | 0.0356 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0052 | 0.0232 | 0.5 |
Echinococcus multilocularis | H(+):Cl() exchange transporter 3 | 0.0052 | 0.0232 | 0.0232 |
Schistosoma mansoni | chloride channel protein | 0.0052 | 0.0232 | 0.0232 |
Chlamydia trachomatis | Mg++ transporter | 0.0052 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0052 | 0.0232 | 0.5 |
Brugia malayi | 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein | 0.0062 | 0.0356 | 0.0126 |
Echinococcus multilocularis | SNF4:AMP activated protein kinase gamma subunit | 0.0052 | 0.0232 | 0.0232 |
Toxoplasma gondii | CBS family protein | 0.0052 | 0.0232 | 1 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0062 | 0.0356 | 0.0126 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0052 | 0.0232 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0052 | 0.0232 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0052 | 0.0232 | 0.5 |
Echinococcus granulosus | H:Cl exchange transporter 3 | 0.0052 | 0.0232 | 0.0232 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0786 | 0.9356 | 0.9356 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0232 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0838 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0052 | 0.0232 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0062 | 0.0356 | 1 |
Treponema pallidum | Mg2+ transport protein (mgtE) | 0.0052 | 0.0232 | 0.5 |
Echinococcus multilocularis | H(+):Cl() exchange transporter 4 | 0.0052 | 0.0232 | 0.0232 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0062 | 0.0356 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0232 | 0.5 |
Schistosoma mansoni | chloride channel protein | 0.0052 | 0.0232 | 0.0232 |
Mycobacterium tuberculosis | Conserved protein | 0.0052 | 0.0232 | 0.5 |
Echinococcus granulosus | SNF4:AMP activated protein kinase gamma subunit | 0.0052 | 0.0232 | 0.0232 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.0052 | 0.0232 | 0.5 |
Echinococcus multilocularis | AMPK beta subunit | 0.0062 | 0.0356 | 0.0356 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0052 | 0.0232 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0054 | 0.0259 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0052 | 0.0232 | 0.0232 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.013 | 0.1199 | 0.1199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.