Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.6557 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.4349 | 0.4263 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.7133 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.7133 | 0.7133 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.7133 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.7133 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.7133 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.4349 | 0.4263 |
Onchocerca volvulus | 0.0027 | 0.4349 | 0.5 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.7133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.42 | 0.42 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.7133 | 0.709 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.4349 | 0.4263 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.4349 | 0.4349 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.4349 | 0.4349 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.6557 | 0.6505 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.7133 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.7133 | 0.6957 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.4349 | 0.4001 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.4349 | 0.4263 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.7133 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.4349 | 0.4263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4349 | 0.4349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.6557 | 0.6505 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0149 | 0.0149 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.6557 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.4349 | 0.4263 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.7133 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.7133 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.4349 | 0.4001 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.7133 | 0.709 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.6557 | 0.6557 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.6557 | 0.6345 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.7133 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.7133 | 0.4927 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.7133 | 0.4927 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.5991 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.058 | 0.058 |
Onchocerca volvulus | 0.0027 | 0.4349 | 0.5 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.7133 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.5991 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.