Detailed information for compound 1477004

Basic information

Technical information
  • TDR Targets ID: 1477004
  • Name: 1-(4-methoxyphenyl)-3-morpholin-4-yl-2-phenyl propan-1-one
  • MW: 325.402 | Formula: C20H23NO3
  • H donors: 0 H acceptors: 1 LogP: 2.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)C(c1ccccc1)CN1CCOCC1
  • InChi: 1S/C20H23NO3/c1-23-18-9-7-17(8-10-18)20(22)19(16-5-3-2-4-6-16)15-21-11-13-24-14-12-21/h2-10,19H,11-15H2,1H3
  • InChiKey: QOABVBAPHTTZBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methoxyphenyl)-3-morpholino-2-phenyl-propan-1-one
  • 1-(4-methoxyphenyl)-3-morpholino-2-phenylpropan-1-one
  • 1-(4-methoxyphenyl)-3-morpholin-4-yl-2-phenyl-propan-1-one
  • Oprea1_111347
  • STOCK2S-38665
  • Propan-1-one, 1-(4-methoxyphenyl)-3-(morpholin-4-yl)-2-phenyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.2973 0.3263 0.4337
Trypanosoma cruzi oligopeptidase b 0.2507 0.2579 0.3271
Entamoeba histolytica prolyl oligopeptidase family protein 0.1079 0.0478 0.5
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.2973 0.3263 0.4337
Echinococcus granulosus Dipeptidyl peptidase 9 0.2973 0.3263 0.3263
Brugia malayi prolyl oligopeptidase family protein 0.5446 0.69 0.6872
Entamoeba histolytica prolyl oligopeptidase family protein 0.1079 0.0478 0.5
Echinococcus granulosus metabotropic glutamate receptor 5 0.1108 0.0521 0.0521
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.5446 0.69 0.69
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1023 0.0396 0.0396
Giardia lamblia Alanyl dipeptidyl peptidase 0.1079 0.0478 0.5
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.2973 0.3263 0.4337
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.2973 0.3263 0.1585
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.7554 1 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.2973 0.3263 0.4337
Trypanosoma brucei prolyl endopeptidase 0.5446 0.69 1
Loa Loa (eye worm) hypothetical protein 0.1079 0.0478 0.0269
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.4367 0.5314 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1079 0.0478 0.5
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1108 0.0521 0.0521
Echinococcus multilocularis prolyl endopeptidase 0.5446 0.69 0.69
Brugia malayi prolyl oligopeptidase family protein 0.1079 0.0478 0.0391
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.1079 0.0478 0.5
Echinococcus granulosus prolyl endopeptidase 0.5446 0.69 0.69
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.2507 0.2579 0.5
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.2507 0.2579 0.3271
Loa Loa (eye worm) hypothetical protein 0.1839 0.1595 0.1411
Brugia malayi Metabotropic glutamate receptor precursor. 0.09 0.0215 0.0126
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.1079 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.1134 0.0559 0.0352
Entamoeba histolytica hypothetical protein, conserved 0.1079 0.0478 0.5
Echinococcus multilocularis Dipeptidyl peptidase 9 0.2973 0.3263 0.3263
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.7554 1 1
Echinococcus granulosus acylamino acid releasing enzyme 0.1079 0.0478 0.0478
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.5446 0.69 0.69
Brugia malayi prolyl oligopeptidase family protein 0.1079 0.0478 0.0391
Entamoeba histolytica prolyl oligopeptidase family protein 0.1079 0.0478 0.5
Plasmodium vivax hypothetical protein, conserved 0.1079 0.0478 0.5
Loa Loa (eye worm) hypothetical protein 0.5446 0.69 0.6832
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1079 0.0478 0.0478
Plasmodium falciparum peptidase, putative 0.1079 0.0478 0.5
Loa Loa (eye worm) prolyl oligopeptidase 0.1079 0.0478 0.0269
Brugia malayi prolyl oligopeptidase family protein 0.2973 0.3263 0.3202
Loa Loa (eye worm) prolyl oligopeptidase 0.7554 1 1
Brugia malayi hypothetical protein 0.1839 0.1595 0.1519
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.2918 0.3182 0.4211
Loa Loa (eye worm) hypothetical protein 0.1108 0.0521 0.0313
Entamoeba histolytica dipeptidyl-peptidase, putative 0.1079 0.0478 0.5
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.7554 1 1
Trypanosoma brucei oligopeptidase b 0.2507 0.2579 0.3271
Trypanosoma cruzi oligopeptidase b 0.2507 0.2579 0.3271
Toxoplasma gondii prolyl endopeptidase 0.5446 0.69 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.7554 1 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.2507 0.2579 0.5
Trichomonas vaginalis conserved hypothetical protein 0.1079 0.0478 0.5
Trypanosoma cruzi prolyl endopeptidase 0.5446 0.69 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.2507 0.2579 0.3271
Giardia lamblia Alanyl dipeptidyl peptidase 0.1079 0.0478 0.5
Echinococcus multilocularis acylamino acid releasing enzyme 0.1079 0.0478 0.0478
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.2507 0.2579 0.3271
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.2507 0.2579 0.3271
Entamoeba histolytica dipeptidyl-peptidase, putative 0.1079 0.0478 0.5
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.5446 0.69 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.2973 0.3263 0.3263

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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