Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0116 | 0.6021 | 0.6021 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0036 | 0.1083 | 0.1083 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0048 | 0.1841 | 0.1841 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0036 | 0.1083 | 0.1083 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0043 | 0.1505 | 0.1505 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1083 | 0.1083 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.1307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6021 | 0.6021 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0095 | 0.4715 | 0.4715 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0105 | 0.5383 | 0.5383 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0052 | 0.2079 | 0.3862 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0105 | 0.5383 | 0.5383 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0105 | 0.5383 | 0.5383 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0036 | 0.1083 | 0.1083 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0027 | 0.0549 | 0.0549 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0105 | 0.5383 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0043 | 0.1505 | 0.1505 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0095 | 0.4715 | 0.8758 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0048 | 0.1841 | 0.1841 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0103 | 0.5249 | 0.975 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0103 | 0.5249 | 0.5249 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1499 | 0.1499 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.1307 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1083 | 0.1083 |
Echinococcus granulosus | potassium voltage gated channel subfamily D | 0.0036 | 0.1083 | 0.1083 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0105 | 0.5383 | 0.5383 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.4962 | 0.4962 |
Loa Loa (eye worm) | Kv4.2 voltage-gated potassium channel | 0.0034 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5383 | 0.5383 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0052 | 0.2079 | 0.3862 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0105 | 0.5383 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0103 | 0.5249 | 0.5249 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0048 | 0.1841 | 0.1841 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0048 | 0.1841 | 0.1841 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 6.3096 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 37.6858 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.