Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.078 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 1 | 0.5 |
Onchocerca volvulus | 0.0065 | 1 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.078 | 0.078 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.078 | 0.078 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.078 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.078 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.