Detailed information for compound 1479245

Basic information

Technical information
  • TDR Targets ID: 1479245
  • Name: 1-(3-methylphenyl)-2,3-dihydropyrrolo[2,3-b]q uinolin-4-amine
  • MW: 275.348 | Formula: C18H17N3
  • H donors: 1 H acceptors: 1 LogP: 3.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)N1CCc2c1nc1ccccc1c2N
  • InChi: 1S/C18H17N3/c1-12-5-4-6-13(11-12)21-10-9-15-17(19)14-7-2-3-8-16(14)20-18(15)21/h2-8,11H,9-10H2,1H3,(H2,19,20)
  • InChiKey: TWKBMFXNTDXITI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(3-methylphenyl)-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl]amine
  • CBDivE_015465
  • BAS 00648627
  • STK022738
  • Oprea1_340959
  • Oprea1_710684
  • EU-0074538

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.154 0.154
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.014 0.0226
Schistosoma mansoni hypothetical protein 0.0084 0.0278 0.0449
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.1057 0.6194 0.6194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0393 0.0635
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0393 0.0635
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.014 0.0226
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.1026 0.1657
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0297 0.048
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0194 0.0314
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0297 0.0297
Mycobacterium leprae Probable lipase LipE 0.0039 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.014 1
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0297 0.048
Trypanosoma cruzi N-myristoyl transferase, putative 0.1057 0.6194 1
Echinococcus granulosus expressed conserved protein 0.0192 0.0931 0.1504
Leishmania major N-myristoyl transferase, putative 0.1057 0.6194 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.014 0.1101
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.154 0.2487
Echinococcus multilocularis protein dispatched 1 0.01 0.0373 0.0373
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.014 0.0226
Trichomonas vaginalis N-myristoyl transferase, putative 0.1057 0.6194 1
Echinococcus multilocularis expressed conserved protein 0.0192 0.0931 0.0931
Trichomonas vaginalis N-myristoyl transferase, putative 0.0694 0.3989 0.644
Toxoplasma gondii ABC1 family protein 0.0039 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.0393 0.0635
Loa Loa (eye worm) hypothetical protein 0.0088 0.0297 0.048
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0115 0.0185
Brugia malayi N-myristoyltransferase 2 0.1057 0.6194 1
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.1057 0.6194 1
Trypanosoma brucei N-myristoyltransferase 0.1057 0.6194 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.014 0.014
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.1057 0.6194 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.014 1
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.1057 0.6194 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0 0.5
Trypanosoma brucei N-myristoyl transferase, putative 0.1057 0.6194 1
Loa Loa (eye worm) N-myristoyltransferase 2 0.1057 0.6194 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.014 0.0226
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.1007 0.1625
Echinococcus multilocularis protein patched 0.0088 0.0297 0.0297
Brugia malayi CHE-14 protein 0.0088 0.0297 0.048
Giardia lamblia CDC72 0.1057 0.6194 0.5
Schistosoma mansoni hypothetical protein 0.0084 0.0278 0.0449
Loa Loa (eye worm) hypothetical protein 0.0107 0.0417 0.0674
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.1007 0.1625
Schistosoma mansoni hypothetical protein 0.0084 0.0278 0.0449
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.1007 0.1007
Onchocerca volvulus 0.0039 0 0.5
Onchocerca volvulus 0.0039 0 0.5
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.1057 0.6194 0.5
Schistosoma mansoni patched 1 0.0088 0.0297 0.048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0393 0.0635
Loa Loa (eye worm) hypothetical protein 0.0204 0.1007 0.1625
Schistosoma mansoni hypothetical protein 0.0071 0.0194 0.0314
Trypanosoma cruzi N-myristoyl transferase, putative 0.1057 0.6194 1
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0297 0.048
Onchocerca volvulus 0.0039 0 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1271 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0194 0.0314
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0297 0.048
Schistosoma mansoni N-myristoyltransferase 0.1057 0.6194 1
Schistosoma mansoni hypothetical protein 0.0084 0.0278 0.0449

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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