TDR Targets

Basic information

Technical information

TDR Targets ID: 1480599
Name: 1-(4-ethoxyphenoxy)-3-[[1-(phenylmethyl)piper idin-4-yl]amino]propan-2-ol
MW: 384.512 | Formula: C23H32N2O3
H donors: 2 H acceptors: 1 LogP: 3.27 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)OCC(CNC1CCN(CC1)Cc1ccccc1)O
InChi: 1S/C23H32N2O3/c1-2-27-22-8-10-23(11-9-22)28-18-21(26)16-24-20-12-14-25(15-13-20)17-19-6-4-3-5-7-19/h3-11,20-21,24,26H,2,12-18H2,1H3
InChiKey: FFZPOJBEZXPEIS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-ethoxyphenoxy)-3-[[1-(phenylmethyl)-4-piperidyl]amino]propan-2-ol
1-(4-ethoxyphenoxy)-3-[[1-(phenylmethyl)-4-piperidinyl]amino]propan-2-ol
1-[[1-(benzyl)-4-piperidyl]amino]-3-(4-ethoxyphenoxy)propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0262
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0114	0.1274	1
Trypanosoma brucei	calpain, putative	0.0114	0.1274	1
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.1106	0.635
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0448	0.3983
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0611	0.3509
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0073	0.0648
Schistosoma mansoni	hypothetical protein	0.0028	0.0217	0.1926
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0448	0.0448
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0073	0.0073
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0073	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1056	0.9388
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0073	0.0418
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0074	0.0425
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0074	0.0003
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0448	0.2573
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0448	0.3983
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0479
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0074	0.0003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.1274	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.1125	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0173	0.0491
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.1056	0.8187
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0405	0.1147
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0016	0.0073	0.7419
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0173	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0066
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0461	0.1307
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0448	0.3983
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0066
Schistosoma mansoni	hypothetical protein	0.0016	0.0074	0.0658
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0499	0.1117
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0073	0.0418
Echinococcus granulosus	GPCR family 2	0.0016	0.0074	0.0425
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0217	0.0377
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Echinococcus granulosus	hypothetical protein	0.0028	0.0217	0.1244
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0448	0.0448
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0499	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0499	0.1117
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.1056	0.2575
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0173	0.0479
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0145	0.1659	1
Loa Loa (eye worm)	tumor suppressor	0.0328	0.3892	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0499	0.1117
Schistosoma mansoni	patched 1	0.0043	0.0405	0.3595
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0611	0.5433
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.1274	1
Brugia malayi	jmjC domain containing protein	0.006	0.0611	0.141
Schistosoma mansoni	hypothetical protein	0.0028	0.0217	0.1926
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0611	0.141
Echinococcus granulosus	expressed conserved protein	0.0094	0.1032	0.5922
Brugia malayi	jmjC domain containing protein	0.006	0.0611	0.141
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0479
Giardia lamblia	Kinase, PLK	0.0096	0.1056	0.2996
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.1274	1
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0073	0.0073
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0405	0.2322
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0073	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0523	0.1179
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0073	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.1056	0.2575
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0303	0.0601
Brugia malayi	CHE-14 protein	0.0043	0.0405	0.0868
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0173	0.0479
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0262
Echinococcus granulosus	protein quaking	0.0028	0.0217	0.1244
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.1106	0.2706
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0405	0.2322
Brugia malayi	Muscleblind-like protein	0.0152	0.1742	0.437
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0262
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.1056	0.8187
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0074	0.0074
Echinococcus multilocularis	protein quaking	0.0028	0.0217	0.0217
Schistosoma mansoni	hypothetical protein	0.0016	0.0074	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1742	0.437
Schistosoma mansoni	hypothetical protein	0.0016	0.0074	0.0658
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.1056	0.8187
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0098	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0448	0.2573
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0173	0.0552
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0145	0.1659	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.1056	1
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0073	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0066
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0611	0.0611
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.1274	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.0491
Echinococcus multilocularis	expressed conserved protein	0.0094	0.1032	0.1032
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0114	0.1274	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0611	0.5433
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0303	0.0601
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0073	0.0648
Echinococcus multilocularis	muscleblind protein	0.0152	0.1742	0.1742
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0074	0.0074
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0074	0.0074
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0611	0.5433
Plasmodium vivax	JmjC domain containing protein	0.0016	0.0073	0.7419
Trypanosoma brucei	hypothetical protein	0.0114	0.1274	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0066
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0405	0.0868
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.1742	0.1742
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0461	0.1307
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0834
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0073	0.0073
Brugia malayi	Temporarily assigned gene name protein 44	0.0028	0.0217	0.0377
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.1056	0.1056
Schistosoma mansoni	hypothetical protein	0.0016	0.0074	0.0658
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0074	0.0003
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0098	1
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0073	0.0648
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0611	0.3509
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0073	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0074	0.0003
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0448	0.0983
Loa Loa (eye worm)	hypothetical protein	0.01	0.1106	0.2706
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0173	0.0491
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.1056	0.6064
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0066
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0448	0.0983
Trypanosoma brucei	polo-like protein kinase	0.0096	0.1056	0.8187
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0479	0.0479
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0298	0.3526	1
Echinococcus granulosus	muscleblind protein	0.0152	0.1742	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0098	0.0077
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0173	0.0262
Brugia malayi	hypothetical protein	0.0028	0.0217	0.0377
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0098	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.1274	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0303	0.2689
Echinococcus multilocularis	protein patched	0.0043	0.0405	0.0405
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.1634	0.1634
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0173	0.0479
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.1106	0.3137
Giardia lamblia	Fructose-bisphosphate aldolase	0.0298	0.3526	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0298	0.3526	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.1106	0.1106
Brugia malayi	tumor suppressor.	0.0328	0.3892	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0073	0.0073
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0262
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0834
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0173	0.0479
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0073	0.0648
Treponema pallidum	fructose-bisphosphate aldolase	0.0298	0.3526	0.5
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0173	0.0834
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.1274	1
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0073	0.0648
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0073	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0298	0.3526	1
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.1274	1
Schistosoma mansoni	kinase	0.0049	0.0476	0.4234
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.1056	0.2996
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Schistosoma mansoni	hypothetical protein	0.0041	0.0386	0.3426
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0145	0.1659	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0405	0.0868
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.1634	0.9378
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0173	0.0552
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0074	0.0425
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0173	0.0479
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.1056	0.2996
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1742	0.437

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1618056

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1480599