TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.422 | Formula: C22H22N2O2
H donors: 1 H acceptors: 2 LogP: 2.34 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(c2ccccc2)C2(C3N1CCC3C2c1ccccc1)C(=O)C
InChi: 1S/C22H22N2O2/c1-14(25)22-18(15-8-4-2-5-9-15)17-12-13-24(20(17)22)21(26)23-19(22)16-10-6-3-7-11-16/h2-11,17-20H,12-13H2,1H3,(H,23,26)
InChiKey: ALNREWIJIWNNFA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0057	0.0165	0.0165
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0623	0.5908	0.8637
Onchocerca volvulus		0.0623	0.5908	0.5908
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0057	0.0165	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0357	0.0448
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0515	0.4814	0.4814
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.002	0.0041
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0076	0.0357	0.0604
Echinococcus multilocularis	transmembrane protease serine 3	0.0097	0.0569	0.0715
Onchocerca volvulus	Putative nachr subunit	0.0076	0.0357	0.0357
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0293	0.2553	0.3733
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0057	0.0165	0.0207
Schistosoma mansoni	hypothetical protein	0.035	0.3132	0.4579
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0076	0.0357	0.0604
Echinococcus multilocularis	nAChR subunit	0.0076	0.0357	0.0448
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0097	0.0569	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Onchocerca volvulus		0.035	0.3132	0.3132
Brugia malayi	CUB domain containing protein	0.0092	0.0516	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0516	0.0516
Onchocerca volvulus		0.0097	0.0569	0.0569
Onchocerca volvulus		0.035	0.3132	0.3132
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0057	0.0165	0.0207
Mycobacterium ulcerans	hypothetical protein	0.0097	0.0569	0.5
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0173	0.1342	0.1962
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0076	0.0357	0.0741
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0076	0.0357	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Brugia malayi	hydrolase, alpha/beta fold family protein	0.0509	0.4754	0.8048
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0357	0.0522
Onchocerca volvulus	Terribly reduced optic lobes homolog	0.0057	0.0165	0.0165
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0057	0.0165	0.0165
Schistosoma mansoni	hypothetical protein	0.0097	0.0569	0.0832
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0357	0.0357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0357	0.0448
Schistosoma mansoni	hypothetical protein	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.035	0.3132	0.3132
Schistosoma mansoni	hypothetical protein	0.0041	0.0004	0.0006
Echinococcus granulosus	transmembrane protease serine 3	0.0097	0.0569	0.1182
Onchocerca volvulus		0.035	0.3132	0.3132
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0057	0.0165	0.0342
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0927	0.0927
Schistosoma mansoni	hypothetical protein	0.0052	0.0115	0.0169
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.06	1
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0052	0.0115	0.5
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0173	0.1342	1
Onchocerca volvulus		0.0293	0.2553	0.2553
Onchocerca volvulus		0.0076	0.0357	0.0357
Brugia malayi	Cation transporter family protein	0.0076	0.0357	0.0604
Onchocerca volvulus	Arrow homolog	0.0057	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Brugia malayi	Trypsin-like protease protein 5	0.0097	0.0569	0.0963
Brugia malayi	enteropeptidase precursor	0.0057	0.0165	0.0279
Plasmodium falciparum	cysteine repeat modular protein 1	0.0052	0.0115	0.5
Echinococcus multilocularis	glycine receptor subunit beta	0.0076	0.0357	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0569	0.0569
Onchocerca volvulus		0.0057	0.0165	0.0165
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0357	0.0741
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0081	0.0102
Loa Loa (eye worm)	trypsin family protein	0.0097	0.0569	0.0569
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0173	0.1342	0.1686
Loa Loa (eye worm)	ACC-1 protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Onchocerca volvulus		0.035	0.3132	0.3132
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0043	0.002	0.002
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0076	0.0357	0.0357
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.002	0.0025
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.06	0.0754
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0515	0.4814	1
Brugia malayi	Cation transporter family protein	0.0293	0.2553	0.4322
Echinococcus granulosus	glycoprotein Antigen 5	0.0097	0.0569	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0569	0.0569
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0057	0.0165	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.0616	0.0901
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0357	0.0448
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0165
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0357	0.0604
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0097	0.0569	0.0715
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0173	0.1342	1
Brugia malayi	Trypsin family protein	0.0097	0.0569	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0076	0.0357	0.0448
Loa Loa (eye worm)	LGC-31 protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0076	0.0357	0.0741
Echinococcus granulosus	glycine receptor subunit beta	0.0076	0.0357	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0569	0.0715
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0357	0.0604
Schistosoma mansoni	hypothetical protein	0.0057	0.0165	0.0241
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0057	0.0165	0.0207
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0115	0.0195
Echinococcus granulosus	Low density lipoprotein receptor class A cysteine rich	0.0057	0.0165	0.0342
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Brugia malayi	Trypsin family protein	0.0097	0.0569	0.0963
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0076	0.0357	0.0741
Onchocerca volvulus		0.0052	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0623	0.5908	0.5908
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0097	0.0569	0.0963
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0076	0.0357	0.0741
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0076	0.0357	0.0357
Loa Loa (eye worm)	TK/ROR protein kinase	0.0052	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0118	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Schistosoma mansoni	hypothetical protein	0.0057	0.0165	0.0241
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0357	0.0741
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Onchocerca volvulus		0.0293	0.2553	0.2553
Onchocerca volvulus		0.0076	0.0357	0.0357
Loa Loa (eye worm)	prolyl oligopeptidase	0.0515	0.4814	0.4814
Echinococcus granulosus	low density lipoprotein receptor protein	0.0057	0.0165	0.0342
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0569	0.0832
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus multilocularis	glycine receptor subunit beta	0.0076	0.0357	0.0448
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.06	0.1016
Brugia malayi	Cation transporter family protein	0.0076	0.0357	0.0604
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0293	0.2553	0.3733
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0076	0.0357	0.0522
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Loa Loa (eye worm)	ACC-1 protein	0.0076	0.0357	0.0357
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0357	0.0741
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0057	0.0165	0.0279
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.1037	0.2154
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0076	0.0357	0.0448
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0076	0.0357	0.0357
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0076	0.0357	0.0604
Brugia malayi	excitatory GABA receptor EXP-1A	0.0076	0.0357	0.0604
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.1037	0.1302
Onchocerca volvulus	Epoxide hydrolase 1 homolog	0.1026	1	1
Onchocerca volvulus		0.0057	0.0165	0.0165
Echinococcus granulosus	glycine receptor subunit beta	0.0076	0.0357	0.0741
Brugia malayi	basement membrane proteoglycan precursor	0.0057	0.0165	0.0279
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0057	0.0165	0.0342
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0057	0.0165	0.0241
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0076	0.0357	0.0448
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0115	0.0115
Onchocerca volvulus		0.035	0.3132	0.3132
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0076	0.0357	0.0448
Echinococcus multilocularis	low density lipoprotein receptor protein	0.0057	0.0165	0.0207
Schistosoma mansoni	hypothetical protein	0.0041	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Echinococcus granulosus	expressed conserved protein	0.0094	0.0539	0.1119
Echinococcus granulosus	nAChR subunit	0.0076	0.0357	0.0741
Schistosoma mansoni	patched 1	0.0043	0.002	0.0029
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0165
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Onchocerca volvulus		0.0057	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0357	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2553	0.2553
Echinococcus granulosus	tissue type plasminogen activator	0.0052	0.0115	0.024
Echinococcus multilocularis	tissue type plasminogen activator	0.0052	0.0115	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0623	0.5908	0.5908
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0173	0.1342	0.5
Echinococcus multilocularis	Mastin	0.0097	0.0569	0.0715
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0057	0.0165	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0357	0.0604
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0357	0.0522
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0057	0.0165	0.0342
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Loa Loa (eye worm)	DOMON domain-containing protein	0.035	0.3132	0.3132
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Onchocerca volvulus		0.0057	0.0165	0.0165
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0076	0.0357	0.0741
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0057	0.0165	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0057	0.0165	0.0342
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus granulosus	enteropeptidase	0.0097	0.0569	0.1182
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0057	0.0165	0.0165
Echinococcus granulosus	Mastin	0.0097	0.0569	0.1182
Brugia malayi	prolyl oligopeptidase family protein	0.0173	0.1342	0.2272
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0076	0.0357	0.0448
Schistosoma mansoni	nAChR subunit	0.0076	0.0357	0.0522
Onchocerca volvulus		0.0097	0.0569	0.0569
Echinococcus multilocularis	glycoprotein Antigen 5	0.0097	0.0569	0.0715
Onchocerca volvulus		0.0097	0.0569	0.0569
Onchocerca volvulus		0.0526	0.4922	0.4922
Brugia malayi	SEA domain containing protein	0.035	0.3132	0.5302
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0076	0.0357	0.0741
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0057	0.0165	0.0207
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0173	0.1342	1
Brugia malayi	Muscle positioning protein 4	0.035	0.3132	0.5302
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0539	0.0677
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0076	0.0357	0.0448
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0057	0.0165	0.0279
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0173	0.1342	0.5
Echinococcus granulosus	5'partial\|Low density lipoprotein receptor class A cysteine rich	0.0057	0.0165	0.0342
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0357	0.0741
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0076	0.0357	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0357	0.0604
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0076	0.0357	0.0604
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Brugia malayi	hypothetical protein	0.0132	0.0927	0.157
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0825	0.7961	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Brugia malayi	CHE-14 protein	0.0043	0.002	0.0033
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0097	0.0569	0.1182
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0076	0.0357	0.0604
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0357	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Brugia malayi	prolyl oligopeptidase family protein	0.0515	0.4814	0.8149
Brugia malayi	Trypsin family protein	0.0623	0.5908	1
Brugia malayi	hypothetical protein	0.0097	0.0569	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0515	0.4814	0.6047
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0165	0.0165
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0173	0.1342	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.035	0.3132	0.3132
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0516	0.0516
Brugia malayi	Kringle domain containing protein	0.0052	0.0115	0.0195
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.06	0.1247
Loa Loa (eye worm)	hypothetical protein	0.01	0.06	0.06
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0076	0.0357	0.0741
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0076	0.0357	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0057	0.0165	0.0165
Brugia malayi	Calcium binding EGF domain containing protein	0.0057	0.0165	0.0279
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0057	0.0165	0.0207
Echinococcus multilocularis	enteropeptidase	0.0097	0.0569	0.0715
Onchocerca volvulus		0.0097	0.0569	0.0569
Echinococcus multilocularis	protein patched	0.0043	0.002	0.0025
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0715	0.684	1
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2553	0.2553
Schistosoma mansoni	cercarial elastase (S01 family)	0.0097	0.0569	0.0832
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.002	0.0041
Schistosoma mansoni	hypothetical protein	0.0041	0.0004	0.0006
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0257	0.2197	0.2197
Schistosoma mansoni	hypothetical protein	0.0041	0.0004	0.0006
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0132	0.092	0.1345
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0569	0.0569
Onchocerca volvulus		0.0057	0.0165	0.0165
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0515	0.4814	0.7038
Onchocerca volvulus		0.0293	0.2553	0.2553
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0173	0.1342	0.2787
Brugia malayi	Trypsin family protein	0.0097	0.0569	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Onchocerca volvulus		0.0097	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0357	0.0357
Onchocerca volvulus		0.0076	0.0357	0.0357
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0569	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0569	0.0569
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0057	0.0165	0.0279

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1722196

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1480831