Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0145 | 0.1406 | 0.1406 |
Onchocerca volvulus | 0.0695 | 1 | 0.5 | |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0695 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0145 | 0.1406 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0145 | 0.1406 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0145 | 0.1406 | 0.1406 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0145 | 0.1406 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0145 | 0.1406 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0753 | 0.0753 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0145 | 0.1406 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0145 | 0.1406 | 0.1406 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0695 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0695 | 1 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0695 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0145 | 0.1406 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0145 | 0.1406 | 0.1406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.