TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.426 | Formula: C21H23N3O2
H donors: 1 H acceptors: 2 LogP: 2.79 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)N1CCCC1=O)Nc1ccccc1N1CCCC1
InChi: 1S/C21H23N3O2/c25-20-8-5-15-24(20)17-11-9-16(10-12-17)21(26)22-18-6-1-2-7-19(18)23-13-3-4-14-23/h1-2,6-7,9-12H,3-5,8,13-15H2,(H,22,26)
InChiKey: UMBSTTJASSWWCI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	growth factor, augmenter of liver regeneration	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	Get druggable targets OG5_127535	All targets in OG5_127535
Schistosoma japonicum	FAD-linked sulfhydryl oxidase ALR, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	Get druggable targets OG5_127535	All targets in OG5_127535
Theileria parva	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Candida albicans	similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Toxoplasma gondii	Erv1 / Alr family protein	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_127535	All targets in OG5_127535
Loa Loa (eye worm)	hepatopoietin HPO2	Get druggable targets OG5_127535	All targets in OG5_127535
Candida albicans	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Babesia bovis	human hepatopoietin-like protein, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	Get druggable targets OG5_127535	All targets in OG5_127535
Toxoplasma gondii	Erv1 / Alr family protein	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Leishmania donovani	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	Get druggable targets OG5_127535	All targets in OG5_127535
Candida albicans	similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase	Get druggable targets OG5_127535	All targets in OG5_127535
Neospora caninum	hypothetical protein	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium berghei	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma congolense	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Plasmodium knowlesi	FAD-linked sulfhydryl oxidase ERV1, putative	Get druggable targets OG5_127535	All targets in OG5_127535
Trypanosoma congolense	ERV/ALR sulfhydryl oxidase domain-containing protein	Get druggable targets OG5_127535	All targets in OG5_127535
Brugia malayi	Augmenter of liver regeneration	Get druggable targets OG5_127535	All targets in OG5_127535

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	protein kinase, putative	0.007	0.2318	1
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Onchocerca volvulus		0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Schistosoma mansoni	tensin-related	0.0093	0.4272	0.2543
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	AGC family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Echinococcus granulosus	expressed conserved protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Onchocerca volvulus		0.0093	0.4272	0.2543
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.007	0.2318	0.2318
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0093	0.4272	0.2543
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0163	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0163	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.007	0.2318	0.2318
Plasmodium vivax	protein kinase, putative	0.007	0.2318	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0163	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0163	1	1
Echinococcus multilocularis	protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	epidermal growth factor receptor	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0163	1	1
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Schistosoma mansoni	SH2A	0.0093	0.4272	0.2543
Giardia lamblia	Kinase, NEK	0.007	0.2318	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0093	0.4272	0.2543
Echinococcus multilocularis		0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0163	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.007	0.2318	0.2318
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.0163	1	1
Schistosoma mansoni	tensin	0.0093	0.4272	0.2543
Brugia malayi	Raf kinase	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0093	0.4272	0.2543
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0163	1	1
Echinococcus multilocularis	SH2 motif	0.0093	0.4272	0.4272
Schistosoma mansoni	suppressor of cytokine signaling	0.0093	0.4272	0.2543
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.1032	0.1032
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.2318	0.2318
Schistosoma mansoni	vav2	0.0093	0.4272	0.2543
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.007	0.2318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Echinococcus multilocularis	activated cdc42 kinase 1	0.007	0.2318	0.2318
Echinococcus granulosus	ephrin type A receptor 4 A	0.007	0.2318	0.2318
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.007	0.2318	0.2318
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.007	0.2318	0.2318
Echinococcus granulosus	epidermal growth factor receptor	0.007	0.2318	0.2318
Echinococcus multilocularis	epidermal growth factor receptor	0.007	0.2318	0.2318
Brugia malayi	protein-tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.007	0.2318	0.2318
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0093	0.4272	0.2543
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0093	0.4272	0.2543
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FAK protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	tensin	0.0093	0.4272	0.4272
Brugia malayi	SH2 domain containing protein	0.0163	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0093	0.4272	0.4272
Echinococcus granulosus	SH2 domain containing protein 7	0.0093	0.4272	0.4272
Echinococcus granulosus	c src tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.007	0.2318	0.2318
Loa Loa (eye worm)	RGC/RGC protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase pr2	0.007	0.2318	0.2318
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0093	0.4272	0.4272
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Plasmodium falciparum	protein kinase, putative	0.007	0.2318	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Echinococcus multilocularis	integrin linked protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	epidermal growth factor receptor	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.007	0.2318	0.2318
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0093	0.4272	0.4272
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0163	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0163	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0163	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.007	0.2318	0.2318
Brugia malayi	hypothetical protein	0.007	0.2318	0.2318
Brugia malayi	Receptor family ligand binding region containing protein	0.007	0.2318	0.2318
Onchocerca volvulus		0.0093	0.4272	0.2543
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Onchocerca volvulus		0.0093	0.4272	0.2543
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0163	1	1
Echinococcus multilocularis	protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Schistosoma mansoni	tensin-related	0.0093	0.4272	0.2543
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.2318	1
Onchocerca volvulus		0.0093	0.4272	0.2543
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Echinococcus multilocularis	natriuretic peptide receptor 1	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Trypanosoma brucei	Flagellum attachment zone protein 20	0.007	0.2318	1
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.007	0.2318	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0163	1	1
Echinococcus granulosus	protein tyrosine kinase	0.007	0.2318	0.2318
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	RGC/RGC protein kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0093	0.4272	0.4272
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/RYK protein kinase	0.007	0.2318	0.2318
Schistosoma mansoni	growth factor receptor-bound protein	0.0093	0.4272	0.2543
Echinococcus granulosus	growth factor receptor bound protein 2	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	protein kinase domain-containing protein	0.007	0.2318	0.2318
Echinococcus multilocularis	kinase suppressor of Ras 1	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Onchocerca volvulus		0.0093	0.4272	0.2543
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Echinococcus granulosus	activin receptor type	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Schistosoma mansoni	GTPase activating protein	0.0093	0.4272	0.2543
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.007	0.2318	0.2318
Plasmodium vivax	tyrosine kinase-like protein, putative	0.007	0.2318	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0093	0.4272	0.2543
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Schistosoma mansoni	nck2/grb4	0.0093	0.4272	0.2543
Brugia malayi	C-terminal src kinase protein 1	0.007	0.2318	0.2318
Brugia malayi	RhoGAP domain containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Schistosoma mansoni	hypothetical protein	0.0093	0.4272	0.2543
Brugia malayi	Protein kinase domain containing protein	0.0163	1	1
Loa Loa (eye worm)	SRC-1	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tensin	0.0093	0.4272	0.4272
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Brugia malayi	Variant SH3 domain containing protein	0.0093	0.4272	0.4272
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0093	0.4272	0.4272
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Giardia lamblia	Kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.007	0.2318	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0093	0.4272	0.4272
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	SH2 motif	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/EGFR protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0163	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0163	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Plasmodium falciparum	protein kinase, putative	0.007	0.2318	1
Brugia malayi	SRC-1	0.0163	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0163	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.007	0.2318	0.2318
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0093	0.4272	0.4272
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	STAT protein	0.0093	0.4272	0.4272
Brugia malayi	hypothetical protein	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Echinococcus granulosus	integrin linked protein kinase	0.007	0.2318	0.2318
Plasmodium falciparum	tyrosine kinase-like protein	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	SH2 domain containing protein	0.0163	1	1
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0163	1	1
Onchocerca volvulus		0.0163	1	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Trypanosoma brucei	protein kinase, putative	0.007	0.2318	1
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.007	0.2318	0.2318
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Leishmania major	protein kinase, putative	0.007	0.2318	1
Brugia malayi	hypothetical protein	0.0163	1	1
Echinococcus multilocularis	SH2 motif	0.0093	0.4272	0.4272
Echinococcus granulosus	activated cdc42 kinase 1	0.007	0.2318	0.2318
Trichomonas vaginalis	CAMK family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.007	0.2318	0.2318
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase Blk	0.0163	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0163	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.007	0.2318	1
Schistosoma mansoni	tensin	0.0093	0.4272	0.2543
Loa Loa (eye worm)	RGC/RGC protein kinase	0.007	0.2318	0.2318
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.007	0.2318	0.2318
Toxoplasma gondii	STE kinase	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.007	0.2318	0.2318
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.007	0.2318	0.2318
Loa Loa (eye worm)	SH2 domain-containing protein	0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine kinase	0.0163	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.007	0.2318	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.007	0.2318	0.2318
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Giardia lamblia	Protein 21.1	0.007	0.2318	0.5
Onchocerca volvulus		0.0163	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0093	0.4272	0.4272
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0093	0.4272	0.4272
Echinococcus granulosus	NCK adaptor protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0163	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Brugia malayi	Variant SH3 domain containing protein	0.0093	0.4272	0.4272
Brugia malayi	Cytochrome P450 family protein	0.0054	0.1032	0.1032
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.007	0.2318	0.2318
Brugia malayi	Variant SH3 domain containing protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	FL cytokine receptor	0.007	0.2318	0.2318
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0093	0.4272	0.4272
Echinococcus granulosus	natriuretic peptide receptor 1	0.007	0.2318	0.2318
Echinococcus granulosus	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/ABL protein kinase	0.0163	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0093	0.4272	0.2543
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0163	1	1
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	N chimaerin	0.0093	0.4272	0.4272
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.007	0.2318	0.2318
Giardia lamblia	Kinase, NEK	0.007	0.2318	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0093	0.4272	0.4272
Leishmania major	hypothetical protein, conserved	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0163	1	1
Echinococcus multilocularis	transfer RNA-Thr	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0093	0.4272	0.4272
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.007	0.2318	0.2318
Trichomonas vaginalis	protein kinase atn1, putative	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine kinase	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Onchocerca volvulus		0.0163	1	1
Echinococcus multilocularis	insulin receptor	0.007	0.2318	0.2318
Brugia malayi	bone morphogenetic protein type 1 receptor	0.007	0.2318	0.2318
Entamoeba histolytica	protein kinase, putative	0.0093	0.4272	0.2543
Trichomonas vaginalis	TK family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	SH2 motif	0.0093	0.4272	0.4272
Brugia malayi	Tyrosine-protein kinase PR2	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.2318	0.2318
Schistosoma mansoni	tensin	0.0093	0.4272	0.2543
Echinococcus multilocularis	tyrosine protein kinase	0.007	0.2318	0.2318
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.2318	1
Loa Loa (eye worm)	TK/Met protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0163	1	1
Echinococcus multilocularis	activin receptor type	0.007	0.2318	0.2318
Echinococcus granulosus	protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0163	1	1
Echinococcus multilocularis	heat shock protein 70	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trypanosoma cruzi	protein kinase, putative	0.007	0.2318	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.2318	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0093	0.4272	0.2543
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Plasmodium falciparum	protein kinase, putative	0.007	0.2318	1
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	hypothetical protein	0.0093	0.4272	0.4272
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0093	0.4272	0.2543
Echinococcus granulosus	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.0163	1	1
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	RGC/RGC protein kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	signal transduction protein lnk realted	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0093	0.4272	0.4272
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0163	1	1
Echinococcus granulosus	SH2 motif	0.0093	0.4272	0.4272
Plasmodium falciparum	tyrosine kinase-like protein	0.007	0.2318	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0163	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.007	0.2318	0.2318
Echinococcus multilocularis	tensin	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/DDR protein kinase	0.007	0.2318	0.2318
Schistosoma mansoni	growth factor receptor-bound protein	0.0093	0.4272	0.2543
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.007	0.2318	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318
Brugia malayi	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	protein KINase family member (kin 25)	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.007	0.2318	0.2318
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0093	0.4272	0.4272
Brugia malayi	Tensin	0.0093	0.4272	0.4272
Echinococcus granulosus	raf serine:threonine protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.007	0.2318	0.2318
Onchocerca volvulus		0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0163	1	1
Trichomonas vaginalis	STE family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0163	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	SH2 domain-containing protein	0.0093	0.4272	0.4272
Brugia malayi	Tyrosine-protein kinase abl-1	0.0163	1	1
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0093	0.4272	0.4272
Schistosoma mansoni	hypothetical protein	0.0093	0.4272	0.2543
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.007	0.2318	0.2318
Brugia malayi	ephrin receptor 1 precursor	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0093	0.4272	0.4272
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.007	0.2318	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.007	0.2318	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.007	0.2318	0.2318
Brugia malayi	Guanylyl cyclase protein 23	0.007	0.2318	0.2318
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.007	0.2318	0.2318
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.007	0.2318	0.2318
Echinococcus multilocularis	SHC transforming protein 3	0.0093	0.4272	0.4272
Trypanosoma cruzi	protein kinase, putative	0.007	0.2318	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0093	0.4272	0.2543
Loa Loa (eye worm)	TK/ROR protein kinase	0.007	0.2318	0.2318
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Toxoplasma gondii	protein kinase	0.007	0.2318	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine kinase	0.007	0.2318	0.2318
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Brugia malayi	Protein kinase domain containing protein	0.0163	1	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.0163	1	1
Onchocerca volvulus		0.0093	0.4272	0.2543
Echinococcus multilocularis	N chimaerin	0.0093	0.4272	0.4272
Loa Loa (eye worm)	TK/FER protein kinase	0.0163	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0093	0.4272	0.4272
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0093	0.4272	0.4272
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0093	0.4272	0.4272
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.007	0.2318	1
Echinococcus multilocularis	protein tyrosine kinase	0.007	0.2318	0.2318
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.007	0.2318	0.2318
Loa Loa (eye worm)	TK protein kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine protein kinase pr2	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4272	0.4272
Onchocerca volvulus		0.0163	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.007	0.2318	0.2318
Brugia malayi	SH2 domain containing protein	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0163	1	1
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Trypanosoma brucei	Pseudokinase, putative	0.007	0.2318	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0163	1	1
Schistosoma mansoni	shc transforming protein	0.0093	0.4272	0.2543
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0093	0.4272	0.2543
Schistosoma mansoni	tyrosine kinase	0.0163	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.007	0.2318	0.2318
Echinococcus granulosus	insulin receptor	0.007	0.2318	0.2318
Brugia malayi	Immunoglobulin I-set domain containing protein	0.007	0.2318	0.2318
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.007	0.2318	0.2318
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Echinococcus multilocularis	NCK adaptor protein	0.0093	0.4272	0.4272
Trichomonas vaginalis	TKL family protein kinase	0.007	0.2318	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0093	0.4272	0.4272
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0093	0.4272	0.4272
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0163	1	1
Schistosoma mansoni	adapter molecule crk	0.0093	0.4272	0.2543
Brugia malayi	Protein kinase domain containing protein	0.007	0.2318	0.2318
Echinococcus granulosus	kinase suppressor of Ras 1	0.007	0.2318	0.2318
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0093	0.4272	0.4272
Brugia malayi	integrin-linked kinase	0.007	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.007	0.2318	0.2318

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 1.554 uM	PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1726568

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1481211