Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0363 | 0.1138 | 0.1315 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2755 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.2393 | 0.8657 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2755 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0363 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0363 | 0.1138 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0363 | 0.1138 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0363 | 0.1138 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.2393 | 0.8657 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2755 | 1 | 1 |
Onchocerca volvulus | 0.0363 | 0.1138 | 0.5 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0363 | 0.1138 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0363 | 0.1138 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0363 | 0.1138 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0363 | 0.1138 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0363 | 0.1138 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2755 | 1 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0363 | 0.1138 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0363 | 0.1138 | 0.1138 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0363 | 0.1138 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0363 | 0.1138 | 0.5 |
Brugia malayi | hypothetical protein | 0.0363 | 0.1138 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0363 | 0.1138 | 0.1138 |
Brugia malayi | SWIRM domain containing protein | 0.0363 | 0.1138 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0363 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0363 | 0.1138 | 0.5 |
Echinococcus multilocularis | 0.0363 | 0.1138 | 0.1138 | |
Schistosoma mansoni | amine oxidase | 0.0363 | 0.1138 | 0.1138 |
Schistosoma mansoni | amine oxidase | 0.0363 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1138 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.