TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.295 | Formula: C16H15NO4
H donors: 2 H acceptors: 3 LogP: 3.17 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(=O)O
InChi: 1S/C16H15NO4/c1-10-3-8-13(16(19)20)14(9-10)17-15(18)11-4-6-12(21-2)7-5-11/h3-9H,1-2H3,(H,17,18)(H,19,20)
InChiKey: CWWPKGOGUNTZCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0139	0.0418	0.0483
Onchocerca volvulus		0.0139	0.0418	0.3599
Loa Loa (eye worm)	melatonin receptor type 1A	0.0139	0.0418	0.3599
Echinococcus multilocularis	sex peptide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	neuropeptide receptor	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	Serotonin receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0312	0.1162	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Toxoplasma gondii	histone lysine-specific demethylase	0.0312	0.1162	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.0418	0.0483
Brugia malayi	ORL1-like opioid receptor	0.0139	0.0418	0.3599
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.0418	0.0418
Schistosoma mansoni	amine GPCR	0.0139	0.0418	0.0418
Echinococcus multilocularis	neuropeptide receptor A26	0.0139	0.0418	0.0418
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0312	0.1162	0.5
Brugia malayi	Melatonin receptor type 1A	0.0139	0.0418	0.3599
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	biogenic amine receptor	0.0139	0.0418	0.0418
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0139	0.0418	0.3599
Brugia malayi	Dopamine receptor	0.0139	0.0418	0.3599
Echinococcus granulosus	g-protein coupled receptor	0.0139	0.0418	0.0483
Schistosoma mansoni	hypothetical protein	0.0139	0.0418	0.0418
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0139	0.0418	0.0483
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	somatostatin receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0139	0.0418	0.0418
Brugia malayi	Dopamine receptor protein 1	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0312	0.1162	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0139	0.0418	0.3599
Echinococcus granulosus	neuropeptide s receptor	0.0139	0.0418	0.0483
Echinococcus granulosus	orexin receptor type 2	0.0139	0.0418	0.0483
Plasmodium falciparum	protoporphyrinogen oxidase	0.0312	0.1162	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.2373	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0139	0.0418	0.3599
Echinococcus granulosus	neuropeptide FF receptor 2	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus granulosus	biogenic amine 5HT receptor	0.0139	0.0418	0.0483
Onchocerca volvulus		0.0139	0.0418	0.3599
Brugia malayi	putative neuropeptide receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0139	0.0418	0.3599
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0139	0.0418	0.0418
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0139	0.0418	0.3599
Echinococcus granulosus	dro:myosuppressin receptor	0.0139	0.0418	0.0483
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0139	0.0418	0.0483
Echinococcus granulosus	serotonin receptor	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus granulosus	7tm_1 domain containing protein	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	putative neuropeptide receptor NPR1	0.0139	0.0418	0.3599
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0139	0.0418	0.3599
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0312	0.1162	0.1162
Onchocerca volvulus		0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Schistosoma mansoni	neuropeptide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	amine GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	hypothetical protein	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus granulosus	g protein coupled receptor	0.0139	0.0418	0.0483
Brugia malayi	neuropeptide F receptor	0.0139	0.0418	0.3599
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.0418	0.0418
Brugia malayi	follicle stimulating hormone receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	growth hormone secretagogue receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	amine GPCR	0.0139	0.0418	0.0418
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0139	0.0418	0.0418
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.0418	0.0483
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0139	0.0418	0.0418
Brugia malayi	G protein-coupled receptor F59B2.13	0.0139	0.0418	0.3599
Loa Loa (eye worm)	G-protein coupled receptor	0.0139	0.0418	0.3599
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0139	0.0418	0.3599
Brugia malayi	Dopamine receptor protein 2	0.0139	0.0418	0.3599
Echinococcus multilocularis	G protein coupled receptor 139	0.0139	0.0418	0.0418
Echinococcus granulosus	neuropeptide receptor	0.0139	0.0418	0.0483
Onchocerca volvulus		0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	amine GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0139	0.0418	0.0418
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0139	0.0418	0.0418
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0312	0.1162	0.5
Schistosoma mansoni	hypothetical protein	0.0139	0.0418	0.0418
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0139	0.0418	0.0418
Echinococcus granulosus	G protein coupled receptor 139	0.0139	0.0418	0.0483
Schistosoma mansoni	amine GPCR	0.0139	0.0418	0.0418
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0312	0.1162	0.1341
Echinococcus multilocularis	fmrfamide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0139	0.0418	0.0418
Schistosoma mansoni	neuropeptide F-like receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Schistosoma mansoni	hypothetical protein	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0139	0.0418	0.0418
Brugia malayi	G-protein coupled receptor	0.0139	0.0418	0.3599
Echinococcus granulosus	hypothetical protein	0.0139	0.0418	0.0483
Echinococcus multilocularis	orexin receptor type 2	0.0139	0.0418	0.0418
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0312	0.1162	0.5
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0312	0.1162	0.5
Brugia malayi	neuropeptide F receptor	0.0139	0.0418	0.3599
Schistosoma mansoni	neuropeptide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	opsin-like receptor	0.0139	0.0418	0.0418
Brugia malayi	sulfakinin receptor protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.2373	1	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.2373	1	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0312	0.1162	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0139	0.0418	0.0483
Schistosoma mansoni	opsin-like receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0312	0.1162	0.1162
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0139	0.0418	0.0483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Echinococcus multilocularis	serotonin receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus granulosus	protoporphyrinogen oxidase	0.2061	0.8661	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Leishmania major	UDP-galactopyranose mutase	0.0312	0.1162	0.5
Brugia malayi	hypothetical protein	0.0312	0.1162	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.2373	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0312	0.1162	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Schistosoma mansoni	biogenic amine receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0312	0.1162	0.1341
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Echinococcus granulosus	g protein coupled receptor	0.0139	0.0418	0.0483
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	RE15519p	0.0139	0.0418	0.3599
Echinococcus granulosus	neuropeptide Y receptor	0.0139	0.0418	0.0483
Brugia malayi	larval opioid receptor	0.0139	0.0418	0.3599
Echinococcus multilocularis	dro:myosuppressin receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0139	0.0418	0.0418
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0139	0.0418	0.3599
Echinococcus granulosus	neuropeptides capa receptor	0.0139	0.0418	0.0483
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	neuropeptide receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	neuropeptide receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0139	0.0418	0.0483
Mycobacterium tuberculosis	Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)	0.2061	0.8661	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0139	0.0418	0.0483
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	neuropeptides capa receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	Serotonin receptor	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	serotonin receptor	0.0139	0.0418	0.0418
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0139	0.0418	0.3599
Schistosoma mansoni	amine oxidase	0.0312	0.1162	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus granulosus	7TM GPCR rhodopsin	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	amine oxidase	0.0312	0.1162	0.1162
Schistosoma mansoni	neuropeptide receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0139	0.0418	0.0483
Schistosoma mansoni	neuropeptide f receptor 76f	0.0139	0.0418	0.0418
Echinococcus multilocularis	neuropeptide Y receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0139	0.0418	0.0483
Schistosoma mansoni	adenoreceptor	0.0139	0.0418	0.0418
Echinococcus multilocularis		0.0312	0.1162	0.1162
Echinococcus granulosus	sex peptide receptor	0.0139	0.0418	0.0483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0139	0.0418	0.0418
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	amine oxidase, flavin-containing family protein	0.0312	0.1162	1
Echinococcus multilocularis	allatostatin A receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	g protein coupled receptor	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0139	0.0418	0.3599
Schistosoma mansoni	myosin xvIII	0.0139	0.0418	0.0418
Echinococcus multilocularis	neuropeptides capa receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	neuropeptides capa receptor	0.0139	0.0418	0.0483
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	histamine h1 receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus multilocularis	g-protein coupled receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	G-protein coupled receptor	0.0139	0.0418	0.3599
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Schistosoma mansoni	biogenic amine receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	neuropeptide Y receptor	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0312	0.1162	1
Brugia malayi	G protein-coupled receptor	0.0139	0.0418	0.3599
Brugia malayi	G-protein coupled receptor	0.0139	0.0418	0.3599
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0312	0.1162	0.5
Echinococcus granulosus	fmrfamide receptor	0.0139	0.0418	0.0483
Loa Loa (eye worm)	TYRA-2 protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0139	0.0418	0.3599
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus multilocularis	fmrfamide receptor	0.0139	0.0418	0.0418
Schistosoma mansoni	opsin-like receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	somatostatin receptor	0.0139	0.0418	0.0483
Onchocerca volvulus		0.0312	0.1162	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0139	0.0418	0.0418
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0139	0.0418	0.0483
Onchocerca volvulus		0.0139	0.0418	0.3599
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0139	0.0418	0.0418
Brugia malayi	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	SWIRM domain containing protein	0.0312	0.1162	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Brugia malayi	GnHR receptor homolog	0.0139	0.0418	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0139	0.0418	0.0418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0139	0.0418	0.0418
Schistosoma mansoni	neuropeptide F-like receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	allatostatin A receptor	0.0139	0.0418	0.0483
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0139	0.0418	0.0418
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0139	0.0418	0.3599
Echinococcus multilocularis	g protein coupled receptor	0.0139	0.0418	0.0418
Echinococcus multilocularis	neuropeptide s receptor	0.0139	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Echinococcus multilocularis	neuropeptide Y receptor	0.0139	0.0418	0.0418
Brugia malayi	AKH receptor	0.0139	0.0418	0.3599
Echinococcus multilocularis	neuropeptide receptor	0.0139	0.0418	0.0418
Echinococcus granulosus	neuropeptide receptor A26	0.0139	0.0418	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0418	0.3599
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0139	0.0418	0.3599

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	25 uM	PUBCHEM_BIOASSAY: G6DPH counterscreen for TbHK1 inhibitors - Analogues series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2230, AID2600, AID449725, AID492951]	ChEMBL.	No reference
IC50 (functional)	> 25 uM	PUBCHEM_BIOASSAY: Confirmation assay for inhibitors of Trypanosoma brucei hexokinase 1-Analogue-first series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2516, AID2560, AID2579, AID2600, AID449725, AID492951]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1714653

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1482835