Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | tubulin beta chain, putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0077 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0077 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0077 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0077 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0077 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0077 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0077 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0077 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0077 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0077 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0077 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0077 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0077 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0077 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0077 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0077 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0077 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0077 | 1 | 1 |
Leishmania major | beta tubulin | 0.0077 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39 ng ml-1 | In vitro cytotoxicity against HT-29 (human colon adenocarcinoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | = 39 ng ml-1 | In vitro cytotoxicity against HT-29 (human colon adenocarcinoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | = 84 ng ml-1 | In vitro cytotoxicity against B16F10 (mouse melanoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | = 84 ng ml-1 | In vitro cytotoxicity against B16F10 (mouse melanoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | = 92 ng ml-1 | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | = 92 ng ml-1 | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | > 100 ng ml-1 | In vitro cytotoxicity against P388 (murine leukemia) cell line. | ChEMBL. | 7914927 |
IC50 (functional) | > 100 ng ml-1 | In vitro cytotoxicity against P388 (murine leukemia) cell line. | ChEMBL. | 7914927 |
Ratio (functional) | = 5.81 | Compound was tested for the concentration of agent which reduces the supernatant protein concentration (tubulin, 1 mg/mL) by 50%; ED50/ED50taxol | ChEMBL. | 7914927 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7914927 | |
Mus musculus | ChEMBL23 | 7914927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.