Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0058 | 0.0325 | 0.1502 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0221 | 0.2164 | 0.3129 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0291 | 0.1347 |
Brugia malayi | Pre-SET motif family protein | 0.0221 | 0.2164 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.191 | 0.2515 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0291 | 0.1347 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0057 | 0.0316 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.0044 | 0.0161 | 0.0745 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0057 | 0.0316 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0221 | 0.2164 | 0.3129 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0044 | 0.0161 | 0.0745 |
Brugia malayi | glutathione reductase | 0.0057 | 0.0316 | 0.0417 |
Brugia malayi | bHLH-PAS transcription factor | 0.0044 | 0.0161 | 0.0212 |
Leishmania major | trypanothione reductase | 0.0057 | 0.0316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.2164 | 0.285 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0335 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.4419 | 0.5819 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0221 | 0.2164 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0335 | 0.0484 |
Onchocerca volvulus | 0.0044 | 0.0161 | 0.0161 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0221 | 0.2164 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0044 | 0.0161 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0221 | 0.2164 | 0.3129 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0221 | 0.2164 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0221 | 0.2164 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0291 | 0.0421 |
Plasmodium falciparum | thioredoxin reductase | 0.0057 | 0.0316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.4276 | 0.5631 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.07 | 0.7594 | 1 |
Onchocerca volvulus | 0.0641 | 0.6917 | 0.6917 | |
Brugia malayi | SET domain containing protein | 0.0428 | 0.4511 | 0.594 |
Trypanosoma brucei | trypanothione reductase | 0.0057 | 0.0316 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0913 | 1 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0057 | 0.0316 | 0.0417 |
Brugia malayi | Pre-SET motif family protein | 0.07 | 0.7594 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0291 | 0.1347 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0335 | 0.0441 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0057 | 0.0316 | 0.0417 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0058 | 0.0325 | 0.1502 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0291 | 0.0384 |
Brugia malayi | hypothetical protein | 0.0198 | 0.191 | 0.2515 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0291 | 0.0421 |
Brugia malayi | hypoxia-induced factor 1 | 0.0183 | 0.1736 | 0.2286 |
Loa Loa (eye worm) | glutathione reductase | 0.0057 | 0.0316 | 0.0417 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0291 | 0.0421 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0641 | 0.6917 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0183 | 0.1736 | 0.2286 |
Plasmodium vivax | SET domain protein, putative | 0.0221 | 0.2164 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0291 | 0.1347 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0291 | 0.0384 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0213 | 0.2072 | 0.9575 |
Plasmodium falciparum | glutathione reductase | 0.0057 | 0.0316 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.