Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0188 | 0.1777 | 0.2353 |
Brugia malayi | PAS domain containing protein | 0.0056 | 0.0177 | 0.0234 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0166 | 0.0818 |
Brugia malayi | Pre-SET motif family protein | 0.0664 | 0.7555 | 1 |
Brugia malayi | glutathione reductase | 0.0054 | 0.0158 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2036 | 0.2539 |
Brugia malayi | hypoxia-induced factor 1 | 0.0173 | 0.1601 | 0.2119 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0209 | 0.2036 | 1 |
Leishmania major | trypanothione reductase | 0.0054 | 0.0158 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0166 | 0.0818 |
Trichomonas vaginalis | set domain proteins, putative | 0.0866 | 1 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0558 | 0.0738 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 0.2717 | 0.346 |
Plasmodium falciparum | glutathione reductase | 0.0054 | 0.0158 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0202 | 0.1942 | 0.9541 |
Schistosoma mansoni | single-minded | 0.0056 | 0.0177 | 0.0015 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0209 | 0.2036 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0054 | 0.0158 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0608 | 0.6867 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0056 | 0.0177 | 0.0015 |
Plasmodium falciparum | thioredoxin reductase | 0.0054 | 0.0158 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0209 | 0.2036 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.0558 | 0.2739 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.0158 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.4182 | 0.5441 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0209 | 0.2036 | 0.279 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0209 | 0.2036 | 0.279 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0664 | 0.7555 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0387 | 0.4188 | 1 |
Onchocerca volvulus | 0.0608 | 0.6867 | 0.6867 | |
Brugia malayi | SET domain containing protein | 0.0406 | 0.4421 | 0.5852 |
Mycobacterium ulcerans | putative regulatory protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0404 | 0.0333 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.0558 | 0.0541 |
Brugia malayi | Fli-1 protein | 0.0265 | 0.2717 | 0.3596 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0173 | 0.1601 | 0.1951 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0209 | 0.2036 | 0.279 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.0558 | 0.2739 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0209 | 0.2036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.4328 | 0.5638 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1777 | 0.219 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0209 | 0.2036 | 0.466 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0054 | 0.0158 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0558 | 0.0738 |
Schistosoma mansoni | ets-related | 0.0265 | 0.2717 | 0.3807 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.0558 | 0.0584 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.2036 | 0.2695 |
Trypanosoma brucei | trypanothione reductase | 0.0054 | 0.0158 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 67.0158 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.