Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.056 | 0.5336 | 0.9852 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.2426 | 0.4479 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0081 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.056 | 0.5336 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0081 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.056 | 0.5336 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0081 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0081 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0081 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.056 | 0.5336 | 0.5336 |
Brugia malayi | hypothetical protein | 0.0262 | 0.2012 | 0.3716 |
Plasmodium falciparum | peptidase, putative | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0567 | 0.5416 | 0.5416 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2012 | 0.3716 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0081 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.056 | 0.5336 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0567 | 0.5416 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0081 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0567 | 0.5416 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0081 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0081 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0567 | 0.5416 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0567 | 0.5416 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.056 | 0.5336 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0567 | 0.5416 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.056 | 0.5336 | 0.9852 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.056 | 0.5336 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.056 | 0.5336 | 0.9852 |
Plasmodium vivax | hypothetical protein, conserved | 0.0081 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0342 | 0.291 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0318 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.