Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 0.0266 | 0.0339 | 0.0339 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0266 | 0.0339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0266 | 0.0339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0266 | 0.0339 | 0.0397 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2024 | 1 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2024 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1758 | 0.8536 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2024 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0266 | 0.0339 | 0.0339 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0266 | 0.0339 | 0.0108 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0266 | 0.0339 | 0.0339 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0266 | 0.0339 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0266 | 0.0339 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0266 | 0.0339 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2024 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0266 | 0.0339 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0266 | 0.0339 | 0.5 |
Onchocerca volvulus | 0.0266 | 0.0339 | 0.5 | |
Schistosoma mansoni | amine oxidase | 0.0266 | 0.0339 | 0.0339 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1758 | 0.8536 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0266 | 0.0339 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0266 | 0.0339 | 0.5 |
Brugia malayi | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0266 | 0.0339 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0266 | 0.0339 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0266 | 0.0339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0339 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0266 | 0.0339 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0266 | 0.0339 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0266 | 0.0339 | 0.0339 |
Leishmania major | UDP-galactopyranose mutase | 0.0266 | 0.0339 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0266 | 0.0339 | 0.0397 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.