Detailed information for compound 1485472

Basic information

Technical information
  • TDR Targets ID: 1485472
  • Name: N-(4-sulfamoylphenyl)acridine-4-carboxamide
  • MW: 377.416 | Formula: C20H15N3O3S
  • H donors: 2 H acceptors: 4 LogP: 2.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc2c1nc1ccccc1c2)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C20H15N3O3S/c21-27(25,26)16-10-8-15(9-11-16)22-20(24)17-6-3-5-14-12-13-4-1-2-7-18(13)23-19(14)17/h1-12H,(H,22,24)(H2,21,25,26)
  • InChiKey: HYUVOKSCGZDKAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-sulfamoylphenyl)-4-acridinecarboxamide
  • 165121-46-0
  • NSC 644043
  • AIDS-138066
  • AIDS138066
  • N-(4-(Aminosulfonyl)phenyl)-4-acridinecarboxamide
  • NSC644043
  • NCI60_014936

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.007 0.2202 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.2202 1
Schistosoma mansoni amine GPCR 0.007 0.2202 0.2598
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.2202 1
Echinococcus granulosus geminin 0.0205 0.8474 1
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.2202 0.2598
Echinococcus multilocularis serotonin receptor 0.007 0.2202 0.2598
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0941 0.1111
Echinococcus granulosus neuropeptide receptor 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.2202 0.2598
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0941 0.1111
Brugia malayi GnHR receptor homolog 0.007 0.2202 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.2202 0.2598
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.2202 0.2598
Trypanosoma brucei Polypeptide deformylase 1 0.0091 0.3142 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.2202 0.2598
Brugia malayi Dopamine receptor 0.007 0.2202 1
Echinococcus granulosus g protein coupled receptor 0.007 0.2202 0.2598
Brugia malayi Dopamine receptor protein 1 0.007 0.2202 1
Brugia malayi sulfakinin receptor protein 0.007 0.2202 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0687 0.2185
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.3142 1
Brugia malayi hypothetical protein 0.007 0.2202 1
Onchocerca volvulus 0.007 0.2202 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis sex peptide receptor 0.007 0.2202 0.2598
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0834 0.3788
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.2202 1
Schistosoma mansoni hypothetical protein 0.007 0.2202 0.2598
Schistosoma mansoni amine GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.2202 0.2598
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.2202 0.2598
Echinococcus granulosus g protein coupled receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Brugia malayi RE15519p 0.007 0.2202 1
Echinococcus granulosus neuropeptide receptor A26 0.007 0.2202 0.2598
Schistosoma mansoni biogenic amine receptor 0.007 0.2202 0.2598
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus granulosus fmrfamide receptor 0.007 0.2202 0.2598
Echinococcus granulosus neuropeptide receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1438 0.6529
Brugia malayi G-protein coupled receptor 0.007 0.2202 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis fmrfamide receptor 0.007 0.2202 0.2598
Schistosoma mansoni hypothetical protein 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.006 0.1724 0.7831
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.2202 0.2598
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus granulosus G protein coupled receptor 139 0.007 0.2202 0.2598
Trypanosoma brucei Peptide deformylase 2 0.0091 0.3142 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0237 1 0.5
Brugia malayi hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1724 0.7831
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.2202 0.2598
Schistosoma mansoni hypothetical protein 0.0205 0.8474 1
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.2202 0.2598
Echinococcus granulosus dna polymerase eta 0.0054 0.1438 0.1697
Echinococcus multilocularis g protein coupled receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1438 0.4575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Echinococcus granulosus serotonin receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni hypothetical protein 0.0205 0.8474 1
Onchocerca volvulus 0.007 0.2202 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.2202 1
Schistosoma mansoni hypothetical protein 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.2202 1
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.2202 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.2202 0.2598
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.2202 1
Onchocerca volvulus 0.007 0.2202 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Brugia malayi ORL1-like opioid receptor 0.007 0.2202 1
Schistosoma mansoni neuropeptide receptor 0.007 0.2202 0.2598
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.2202 0.2598
Brugia malayi hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis neuropeptide receptor 0.007 0.2202 0.2598
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0237 1 1
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0941 0.1111
Brugia malayi hypothetical protein 0.007 0.2202 1
Onchocerca volvulus 0.007 0.2202 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.2202 0.2598
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Treponema pallidum polypeptide deformylase (def) 0.0237 1 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.2202 0.2598
Echinococcus multilocularis neuropeptide receptor 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.2202 0.2598
Brugia malayi Serotonin receptor 0.007 0.2202 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1438 0.4575
Schistosoma mansoni adenoreceptor 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus granulosus neuropeptides capa receptor 0.007 0.2202 0.2598
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.2202 0.2598
Brugia malayi hypothetical protein 0.007 0.2202 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.3142 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.2202 0.2598
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.2202 0.5
Echinococcus multilocularis neuropeptide s receptor 0.007 0.2202 0.2598
Schistosoma mansoni amine GPCR 0.007 0.2202 0.2598
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0237 1 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) TYRA-2 protein 0.007 0.2202 1
Entamoeba histolytica hypothetical protein 0.0043 0.0941 1
Toxoplasma gondii hypothetical protein 0.0237 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.2202 0.2598
Brugia malayi AKH receptor 0.007 0.2202 1
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1438 0.6529
Brugia malayi larval opioid receptor 0.007 0.2202 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.2202 0.2598
Echinococcus granulosus sex peptide receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Leishmania major polypeptide deformylase-like protein, putative 0.0091 0.3142 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.2202 0.2598
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.2202 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.2202 0.2598
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.2202 0.2598
Echinococcus granulosus neuropeptide Y receptor 0.007 0.2202 0.2598
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.2202 0.2598
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni hypothetical protein 0.0041 0.0834 0.0984
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.2202 0.2598
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.2202 0.2598
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.2202 0.2598
Brugia malayi follicle stimulating hormone receptor 0.007 0.2202 1
Brugia malayi hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus neuropeptide Y receptor 0.007 0.2202 0.2598
Echinococcus granulosus neuropeptide s receptor 0.007 0.2202 0.2598
Entamoeba histolytica hypothetical protein 0.0043 0.0941 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0687 0.2185
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus multilocularis dna polymerase eta 0.0054 0.1438 0.1697
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.2202 0.2598
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.2202 0.2598
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.2202 1
Echinococcus granulosus g protein coupled receptor 0.007 0.2202 0.2598
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.3142 1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.2202 0.2598
Brugia malayi hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni biogenic amine receptor 0.007 0.2202 0.2598
Brugia malayi G-protein coupled receptor 0.007 0.2202 1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.0041 0.0834 0.3788
Echinococcus multilocularis orexin receptor type 2 0.007 0.2202 0.2598
Echinococcus multilocularis g-protein coupled receptor 0.007 0.2202 0.2598
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.2202 0.2598
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.2202 0.2598
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.2202 1
Brugia malayi hypothetical protein 0.007 0.2202 1
Echinococcus granulosus hypothetical protein 0.007 0.2202 0.2598
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Brugia malayi neuropeptide F receptor 0.007 0.2202 1
Echinococcus multilocularis somatostatin receptor 0.007 0.2202 0.2598
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.2202 0.2598
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.3142 1
Echinococcus multilocularis allatostatin A receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.1438 0.1697
Schistosoma mansoni hypothetical protein 0.0043 0.0941 0.1111
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.2202 0.2598
Echinococcus multilocularis serotonin receptor 0.007 0.2202 0.2598
Schistosoma mansoni neuropeptide receptor 0.007 0.2202 0.2598
Brugia malayi G protein-coupled receptor 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Brugia malayi Melatonin receptor type 1A 0.007 0.2202 1
Echinococcus granulosus somatostatin receptor 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni opsin-like receptor 0.007 0.2202 0.2598
Echinococcus granulosus neuropeptides capa receptor 0.007 0.2202 0.2598
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.2202 0.2598
Echinococcus multilocularis g protein coupled receptor 0.007 0.2202 0.2598
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.2202 0.2598
Schistosoma mansoni amine GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.2202 1
Onchocerca volvulus 0.007 0.2202 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.2202 0.2598
Brugia malayi neuropeptide F receptor 0.007 0.2202 1
Schistosoma mansoni myosin xvIII 0.007 0.2202 0.2598
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1724 0.7831
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1724 0.7831
Echinococcus multilocularis geminin 0.0205 0.8474 1
Onchocerca volvulus 0.007 0.2202 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.2202 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.2202 0.2598
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.2202 0.2598
Echinococcus multilocularis fmrfamide receptor 0.007 0.2202 0.2598
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.2202 0.2598
Schistosoma mansoni neuropeptide receptor 0.007 0.2202 0.2598
Echinococcus granulosus orexin receptor type 2 0.007 0.2202 0.2598
Entamoeba histolytica hypothetical protein 0.0043 0.0941 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.2202 1
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.2202 0.2598
Echinococcus granulosus allatostatin A receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus g-protein coupled receptor 0.007 0.2202 0.2598
Schistosoma mansoni biogenic amine receptor 0.007 0.2202 0.2598
Entamoeba histolytica hypothetical protein 0.0043 0.0941 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni histamine h1 receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Plasmodium falciparum peptide deformylase 0.0237 1 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.2202 0.2598
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.2202 0.2598
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.2202 0.2598
Leishmania major DNA polymerase eta, putative 0.0054 0.1438 0.4575
Brugia malayi Dopamine receptor protein 2 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.2202 1
Schistosoma mansoni hypothetical protein 0.007 0.2202 0.2598
Giardia lamblia DINP protein human, muc B family 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.2202 0.2598
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.2202 0.2598
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.2202 0.2598
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus multilocularis g protein coupled receptor 0.007 0.2202 0.2598
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0 0.5
Brugia malayi Serotonin receptor 0.007 0.2202 1
Brugia malayi putative neuropeptide receptor 0.007 0.2202 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni opsin-like receptor 0.007 0.2202 0.2598
Mycobacterium ulcerans peptide deformylase 0.0237 1 1
Onchocerca volvulus 0.007 0.2202 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni amine GPCR 0.007 0.2202 0.2598
Plasmodium vivax peptide deformylase, putative 0.0237 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Schistosoma mansoni opsin-like receptor 0.007 0.2202 0.2598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.2202 0.2598
Loa Loa (eye worm) hypothetical protein 0.007 0.2202 1
Onchocerca volvulus 0.007 0.2202 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.2202 0.2598
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.2202 0.2598
Brugia malayi hypothetical protein 0.0043 0.0941 0.4275
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.2202 1
Brugia malayi hypothetical protein 0.007 0.2202 1
Schistosoma mansoni neuropeptide receptor 0.007 0.2202 0.2598

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.178 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.093 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.912 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.887 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.861 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.82 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.761 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.688 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.681 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.586 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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