Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0213 | 0.0735 | 0.5 |
Brugia malayi | hypothetical protein | 0.0213 | 0.0735 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0213 | 0.0735 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0213 | 0.0735 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0213 | 0.0735 | 0.0735 |
Schistosoma mansoni | amine oxidase | 0.0213 | 0.0735 | 0.0735 |
Schistosoma mansoni | amine oxidase | 0.0213 | 0.0735 | 0.0735 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0213 | 0.0735 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0213 | 0.0735 | 0.0735 |
Plasmodium vivax | hypothetical protein, conserved | 0.0213 | 0.0735 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Echinococcus multilocularis | 0.0213 | 0.0735 | 0.0735 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0213 | 0.0735 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0213 | 0.0735 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0213 | 0.0735 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.162 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0213 | 0.0735 | 0.0855 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.162 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1407 | 0.8596 | 1 |
Onchocerca volvulus | 0.0213 | 0.0735 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0213 | 0.0735 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.162 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0213 | 0.0735 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0213 | 0.0735 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0213 | 0.0735 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.162 | 1 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0213 | 0.0735 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.0735 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0213 | 0.0735 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0213 | 0.0735 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1407 | 0.8596 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.