Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | plexin A | 0.0176 | 0.6953 | 0.6953 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0225 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0225 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0225 | 1 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0225 | 1 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0225 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0225 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0225 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0225 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0225 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0225 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8728 | 0.8728 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8728 | 0.8728 |
Onchocerca volvulus | 0.0148 | 0.529 | 0.529 | |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0225 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0225 | 1 | 0.5 |
Schistosoma mansoni | plexin | 0.0086 | 0.1493 | 0.1493 |
Echinococcus multilocularis | plexin a4 | 0.0176 | 0.6953 | 0.6953 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.1493 | 0.1493 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0225 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0225 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1493 | 0.1493 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0225 | 1 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0176 | 0.6953 | 0.6953 |
Echinococcus granulosus | plexin a4 | 0.0176 | 0.6953 | 0.6953 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0225 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.529 | 0.529 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0225 | 1 | 1 |
Schistosoma mansoni | plexin | 0.0148 | 0.529 | 0.529 |
Echinococcus granulosus | geminin | 0.0205 | 0.8728 | 0.8728 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0225 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0225 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8728 | 0.8728 |
Brugia malayi | Plexin repeat family protein | 0.0148 | 0.529 | 0.529 |
Plasmodium vivax | RNA helicase-1, putative | 0.0225 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 5.1735 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.