Detailed information for compound 1487074

Basic information

Technical information
  • TDR Targets ID: 1487074
  • Name: T5365402
  • MW: 314.379 | Formula: C18H22N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1ccccc1)C(=O)NNC(=O)c1cc(oc1C)C
  • InChi: 1S/C18H22N2O3/c1-4-8-15(14-9-6-5-7-10-14)17(21)19-20-18(22)16-11-12(2)23-13(16)3/h5-7,9-11,15H,4,8H2,1-3H3,(H,19,21)(H,20,22)
  • InChiKey: FMTQVUIBSJGEBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0073 0.0188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0427 0.2022
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Onchocerca volvulus 0.0014 0.0025 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0073 0.0188
Leishmania major hypothetical protein, conserved 0.003 0.041 0.7572
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0412 0.1951
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0427 0.2022
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0437 0.1973
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0412 0.1065
Schistosoma mansoni glucose transport protein 0.0102 0.2114 0.5462
Onchocerca volvulus Putative transporter 0.0014 0.0025 1
Trypanosoma cruzi hexose transporter 0.0032 0.0437 0.8107
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0025 0.0118
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0437 0.1973
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0188
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0226 0.5182
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0023
Echinococcus granulosus solute carrier family 22 0.0014 0.0025 0.0064
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0412 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Schistosoma mansoni protein kinase 0.0031 0.0427 0.1104
Schistosoma mansoni protein kinase 0.0031 0.0427 0.1104
Leishmania major protein kinase, putative 0.0031 0.0427 0.7919
Schistosoma mansoni sugar transporter 0.0014 0.0025 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.041 0.0386
Onchocerca volvulus 0.0014 0.0025 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0533 1
Brugia malayi Sugar transporter family protein 0.0014 0.0025 0.0118
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0025 0.0118
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0427 0.1104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0915 0.4328
Brugia malayi hypothetical protein 0.002 0.0152 0.072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0575 0.272
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.041 0.7572
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0226 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0009 0.0023
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0025 0.0118
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0226 0.3046
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0025 0.0118
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0428 0.0617
Loa Loa (eye worm) hypothetical protein 0.0063 0.1189 0.5627
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0226 0.0583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0412 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Leishmania major glucose transporter, lmgt3 0.0032 0.0437 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0144 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0427 0.2022
Echinococcus granulosus solute carrier family 22 0.0014 0.0025 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0188
Echinococcus multilocularis solute carrier family 22 0.0014 0.0025 0.0064
Loa Loa (eye worm) hypothetical protein 0.003 0.041 0.1938
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0437 0.8107
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0381 0.0985
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0025 0.0064
Onchocerca volvulus 0.0014 0.0025 1
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.2081 0.5378
Onchocerca volvulus 0.0014 0.0025 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 1 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0428 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0095 0.1383
Loa Loa (eye worm) hypothetical protein 0.0035 0.0525 0.2484
Brugia malayi hypothetical protein 0.0014 0.0025 0.0118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0009 0.0023
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0025 0.0064
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0533 0.0779
Brugia malayi hypothetical protein 0.0014 0.0025 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2114 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0025 0.0118
Schistosoma mansoni transient receptor potential channel 0.0066 0.1269 0.328
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Onchocerca volvulus 0.0014 0.0025 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0025 0.0064
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0025 0.0064
Onchocerca volvulus 0.0014 0.0025 1
Schistosoma mansoni sugar transporter 0.0014 0.0025 0.0064
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.2001 0.5172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Plasmodium vivax hexose transporter 0.0102 0.2114 0.2094
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0412 0.1951
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0412 0.1855
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0428 0.0404
Schistosoma mansoni protein kinase 0.0031 0.0427 0.1104
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0226 0.395
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0226 0.0201
Loa Loa (eye worm) sugar transporter 0.0014 0.0025 0.0118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0073 0.0188
Onchocerca volvulus 0.0014 0.0025 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Onchocerca volvulus 0.0014 0.0025 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0344
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.041 0.059
Echinococcus multilocularis geminin 0.0175 0.387 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0025 0.0064
Onchocerca volvulus 0.0014 0.0025 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.8107
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.1269 0.328
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0427 0.2022
Schistosoma mansoni glucose transporter 0.0014 0.0025 0.0064
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0533 0.051
Loa Loa (eye worm) sugar transporter 0.0102 0.2114 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0226 0.0201
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0575 0.1486
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0073 0.0344
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0533 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0428 0.0617
Onchocerca volvulus 0.0014 0.0025 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0226 0.0583
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0073 0.0188
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0226 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.8107
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0428 0.0404
Brugia malayi Sugar transporter family protein 0.0102 0.2114 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0276 0.1304
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0428 0.0404
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0428 0.0404
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0427 0.7919
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0073 0.0344
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0159 0.0641
Echinococcus multilocularis solute carrier family 22 0.0014 0.0025 0.0064
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2114 0.5462
Schistosoma mansoni hypothetical protein 0.0102 0.2114 0.5462
Echinococcus granulosus geminin 0.0175 0.387 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0025 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0437 0.1973
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0575 0.272
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.1269 0.328
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0428 0.0404
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0226 0.0583
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0575 0.1486
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0915 0.4328
Schistosoma mansoni glucose transport protein 0.0102 0.2114 0.5462
Schistosoma mansoni hypothetical protein 0.0175 0.387 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0412 0.1065
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0381 0.0985
Echinococcus multilocularis GPCR, family 2 0.0016 0.0073 0.0188
Schistosoma mansoni sugar transporter 0.0014 0.0025 0.0064
Schistosoma mansoni sugar transporter 0.0014 0.0025 0.0064
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Trypanosoma brucei glucose transporter 1E 0.0032 0.0437 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0428 0.0617
Loa Loa (eye worm) hypothetical protein 0.01 0.2081 0.9847
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0428 0.0404
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0525 0.2484
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0428 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0533 0.051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0412 0.1951
Echinococcus multilocularis General substrate transporter 0.0088 0.1772 0.4579
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0412 0.1065
Entamoeba histolytica protein kinase, putative 0.0031 0.0427 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.1269 0.328
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0412 0.1065
Plasmodium falciparum hexose transporter 0.0102 0.2114 0.2094
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0025 0.5
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0226 0.1067
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0437 0.8107
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0226 1
Leishmania major glucose transporter, lmgt1 0.0032 0.0437 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0427 0.1104
Schistosoma mansoni transient receptor potential channel 0.01 0.2081 0.5378
Onchocerca volvulus 0.0014 0.0025 1
Brugia malayi hypothetical protein 0.003 0.041 0.1938
Echinococcus granulosus GPCR family 2 0.0016 0.0073 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.2081 0.5378
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0427 0.1104
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0188
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0226 0.395
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.2001 0.5172
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.041 0.0386
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0428 0.0404
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0025 0.0118
Onchocerca volvulus 0.0014 0.0025 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.041 0.7572
Onchocerca volvulus 0.0014 0.0025 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0025 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Loa Loa (eye worm) hypothetical protein 0.0034 0.0495 0.2342
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0412 0.1951
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0025 0.0064
Schistosoma mansoni hypothetical protein 0.0175 0.387 1
Onchocerca volvulus 0.0014 0.0025 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0437 0.8107
Schistosoma mansoni transient receptor potential channel 4 0.01 0.2081 0.5378
Onchocerca volvulus 0.0014 0.0025 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0427 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0915 0.4328
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3611 0.5495
Plasmodium falciparum protein kinase 7 0.0288 0.6551 0.6542
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0915 0.4328
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0533 1
Schistosoma mansoni hypothetical protein 0.0016 0.0073 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0226 0.1067
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0226 0.0583
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3611 0.3595
Schistosoma mansoni glucose transport protein 0.0102 0.2114 0.5462
Schistosoma mansoni transient receptor potential channel 0.0066 0.1269 0.328
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3611 0.3595
Leishmania major glucose transporter, lmgt2 0.0032 0.0437 0.8107
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0073 0.0344
Echinococcus granulosus General substrate transporter 0.0088 0.1772 0.4579
Brugia malayi hypothetical protein 0.0014 0.0025 0.0118
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.1269 0.328
Onchocerca volvulus 0.0014 0.0025 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.041 0.0386
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0025 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0226 0.395
Echinococcus multilocularis solute carrier family 22 0.0014 0.0025 0.0064
Brugia malayi Cam kinase protein 1 0.0031 0.0427 0.2022
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0437 0.8107
Toxoplasma gondii protein kinase, putative 0.0288 0.6551 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2114 0.5462
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0437 0.1973
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Schistosoma mansoni hypothetical protein 0.0035 0.0525 0.1357
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0412 0.9253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0226 0.0961
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2114 0.3201
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.041 0.7572
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0144 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0437 0.8107
Brugia malayi Sugar transporter family protein 0.0014 0.0025 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0437 0.1973
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0427 0.1927

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 31.691 uM PUBCHEM_BIOASSAY: High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488938] ChEMBL. No reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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