TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.54 | Formula: C21H30N2O2S
H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1cccc(c1)CNC(=O)C1CCC(=O)N(C1)CC1CCCCC1
InChi: 1S/C21H30N2O2S/c1-26-19-9-5-8-17(12-19)13-22-21(25)18-10-11-20(24)23(15-18)14-16-6-3-2-4-7-16/h5,8-9,12,16,18H,2-4,6-7,10-11,13-15H2,1H3,(H,22,25)
InChiKey: RBYOWENNSZXWTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1973
Schistosoma mansoni	hypothetical protein	0.0177	0.3879	1
Schistosoma mansoni	transient receptor potential channel	0.0102	0.2094	0.5379
Leishmania major	protein kinase, putative	0.0032	0.0444	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	hypothetical protein	0.0017	0.0102	0.0405
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3622	0.5495
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.015	0.0344
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.1067
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Onchocerca volvulus		0.0014	0.0042	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0323	0.5525
Schistosoma mansoni	hypothetical protein	0.0103	0.2128	0.5465
Onchocerca volvulus		0.0014	0.0042	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	major facilitator superfamily protein	0.0014	0.0042	0.012
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.015	0.063
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Schistosoma mansoni	transient receptor potential channel	0.0067	0.1284	0.3281
Schistosoma mansoni	sugar transporter	0.0014	0.0042	0.0066
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0323	0.5525
Onchocerca volvulus		0.0014	0.0042	1
Plasmodium falciparum	protein kinase 7	0.0291	0.6557	0.6542
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	0.5465
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0323	0.5525
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.0017	0.008
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0042	0.0066
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0445	0.0404
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.9253
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1973
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0161	1
Schistosoma mansoni	hypothetical protein	0.0177	0.3879	1
Echinococcus multilocularis	short transient receptor potential channel 6	0.0067	0.1284	0.3281
Schistosoma mansoni	hypothetical protein	0.0041	0.0671	0.1693
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Onchocerca volvulus		0.0014	0.0042	1
Onchocerca volvulus		0.0014	0.0042	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0585
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0243	0.107
Leishmania major	glucose transporter, lmgt1	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	transient receptor potential channel 4	0.0102	0.2094	0.5379
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.1067
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0444	0.1106
Echinococcus granulosus	General substrate transporter	0.0089	0.1787	0.4581
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1953
Echinococcus granulosus	short transient receptor potential channel 6	0.0067	0.1284	0.3281
Schistosoma mansoni	glucose transporter	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Onchocerca volvulus	Putative transporter	0.0014	0.0042	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2128	0.3201
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.1067
Leishmania major	glucose transporter, lmgt3	0.0032	0.0454	0.8107
Echinococcus granulosus	transient receptor potential gamma protein	0.0102	0.2094	0.5379
Onchocerca volvulus		0.0014	0.0042	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0066
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.015	0.063
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0437	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	sugar transporter	0.0103	0.2128	1
Schistosoma mansoni	sugar transporter	0.0014	0.0042	0.0066
Onchocerca volvulus		0.0014	0.0042	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2128	0.5465
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.055	0.051
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0017	0.008
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0042	0.0066
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.055	0.051
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0243	0.5182
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0017	0.008
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0013	0.0017	0.008
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0444	0.1927
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Echinococcus multilocularis	GPCR, family 2	0.0019	0.015	0.0344
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	0.5465
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0243	0.0201
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0243	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Onchocerca volvulus		0.0014	0.0042	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0323	0.5525
Brugia malayi	major facilitator superfamily protein	0.0014	0.0042	0.012
Echinococcus granulosus	geminin	0.0177	0.3879	1
Onchocerca volvulus		0.0014	0.0042	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.015	0.0344
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0445	0.0404
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0243	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0042	0.0066
Plasmodium falciparum	hexose transporter	0.0103	0.2128	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0042	0.0066
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0445	0.0617
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.015	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0444	0.2024
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0161	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0066
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0445	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0323	0.043
Onchocerca volvulus		0.0014	0.0042	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	Sugar transporter family protein	0.0014	0.0042	0.012
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1119	0.5223
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0176	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0671	0.3152
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0398	0.0987
Onchocerca volvulus		0.0014	0.0042	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	sugar transporter	0.0014	0.0042	0.0199
Onchocerca volvulus		0.0014	0.0042	1
Toxoplasma gondii	protein kinase, putative	0.0291	0.6557	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3622	0.3595
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1119	0.5223
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0038	0.0591	0.1487
Loa Loa (eye worm)	hypothetical protein	0.006	0.1119	0.5262
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	short transient receptor potential channel 6	0.0067	0.1284	0.3281
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0017	0.008
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0445	0.0404
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3622	0.3595
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	General substrate transporter	0.0089	0.1787	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	hypothetical protein	0.0019	0.015	0.0344
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0398	0.0987
Echinococcus multilocularis	transient receptor potential ion channel A	0.0098	0.2015	0.5172
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0042	0.012
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0511	0.2404
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	Sugar transporter family protein	0.0103	0.2128	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0243	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0323	0.0282
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0429	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	hypothetical protein	0.0014	0.0042	0.012
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	hypothetical protein	0.0014	0.0042	0.012
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0243	0.0201
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0042	0.012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0445	0.0404
Entamoeba histolytica	protein kinase, putative	0.0032	0.0444	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Echinococcus multilocularis	geminin	0.0177	0.3879	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1119	0.5262
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0445	0.0404
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0019	0.015	0.0705
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0444	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	GPCR family 2	0.0019	0.015	0.0344
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0017	0.008
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0671	0.3097
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0243	0.0308
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0444	0.1106
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0445	0.0404
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus multilocularis	transient receptor potential gamma protein	0.0102	0.2094	0.5379
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0042	0.5
Brugia malayi	hypothetical protein	0.0026	0.0323	0.1448
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Schistosoma mansoni	hypothetical protein	0.0019	0.015	0.0344
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Entamoeba histolytica	protein kinase, putative	0.0032	0.0444	1
Leishmania major	glucose transporter, lmgt2	0.0032	0.0454	0.8107
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2094	0.9844
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	Cam kinase protein 1	0.0032	0.0444	0.2024
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	transient receptor potential ion channel A	0.0098	0.2015	0.5172
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0066
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0445	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1973
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1973
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0042	0.012
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0066
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0445	0.0404
Echinococcus multilocularis	short transient receptor potential channel 6	0.0067	0.1284	0.3281
Onchocerca volvulus		0.0014	0.0042	1
Onchocerca volvulus		0.0014	0.0042	1
Schistosoma mansoni	sugar transporter	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	transient receptor potential channel	0.0067	0.1284	0.3281
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	0.5465
Schistosoma mansoni	hypothetical protein	0.0019	0.015	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0591	0.2779
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus granulosus	TRP transient receptor potential channel	0.0038	0.0591	0.1487
Onchocerca volvulus		0.0014	0.0042	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0293	0.1375
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	hypothetical protein	0.0014	0.0042	0.012
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.1067
Schistosoma mansoni	hypothetical protein	0.0019	0.015	0.0344
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Brugia malayi	Transient-receptor-potential like protein	0.0038	0.0591	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.015	0.0705
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.055	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Onchocerca volvulus		0.0014	0.0042	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0429	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	sugar transporter	0.0014	0.0042	0.0066
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0445	0.0617
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.015	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Trypanosoma cruzi	hexose transporter	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.1517
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.1141
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0454	0.8107
Plasmodium vivax	hexose transporter	0.0103	0.2128	0.2094
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.0017	0.008
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0113	0.1383
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0323	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0323	0.0282
Brugia malayi	Sugar transporter family protein	0.0014	0.0042	0.012
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1106
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0243	0.3046
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1204	0.566

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1718131

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1487086