Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0086 | 0.0119 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0086 | 0.0119 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.001 | 0.014 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0466 | 0.0646 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0086 | 0.1849 |
Brugia malayi | hypothetical protein | 0.0043 | 0.001 | 0.0014 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0615 | 0.2596 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0466 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0739 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1637 | 0.7218 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0615 | 0.2596 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0615 | 0.2596 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0615 | 0.2596 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0466 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0086 | 0.1849 |
Echinococcus granulosus | geminin | 0.0205 | 0.0739 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.001 | 0.014 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0739 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 190.1154 uM | PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.