Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) | Peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania braziliensis | polypeptide deformylase-like protein, putative | Peptide deformylase | 168 aa | 142 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.3598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1188 | 0.4377 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0133 | 0.0489 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.1325 | 0.3592 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2956 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0097 | 0.2578 | 0.7057 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0133 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.1325 | 0.3441 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0133 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0718 | 0.2646 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0133 | 0.1221 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0133 | 0.023 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0133 | 0.0489 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.01 | 0.2715 | 0.7452 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.2097 | 0.5768 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.01 | 0.2715 | 0.751 |
Onchocerca volvulus | 0.0037 | 0.0133 | 0.5 | |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.3598 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0133 | 0.1221 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2715 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0133 | 0.1221 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0051 | 0.0189 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0504 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0066 | 0.1325 | 0.3592 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0133 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0133 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0133 | 0.023 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2956 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0097 | 0.2578 | 0.7057 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 0.5 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.0137 | 0.0012 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.3598 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.1325 | 0.3441 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2956 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.01 | 0.2715 | 0.7452 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0133 | 0.1221 |
Onchocerca volvulus | 0.0037 | 0.0133 | 0.5 | |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0133 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.1325 | 0.3441 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.01 | 0.2715 | 0.751 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0718 | 0.2646 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.0137 | 0.0012 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.0137 | 0.1281 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.8337 | 0.8315 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2956 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2956 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.1325 | 0.3441 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0133 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0133 | 0.0489 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 41 nM | Inhibition of Pseudomonas aeruginosa peptide deformylase after 10 mins by fluorescence assay | ChEMBL. | 21146987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.