Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0327 | 0.1255 | 0.1244 |
Schistosoma mansoni | nck2/grb4 | 0.0032 | 0.006 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0327 | 0.1255 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0032 | 0.006 | 0.037 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0037 | 0.0079 | 0.0074 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0037 | 0.0079 | 0.0064 |
Brugia malayi | Variant SH3 domain containing protein | 0.0025 | 0.0032 | 0.0141 |
Brugia malayi | SWIRM domain containing protein | 0.0327 | 0.1255 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0327 | 0.1255 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0117 | 0.0405 | 0.0391 |
Echinococcus granulosus | NCK adaptor protein | 0.0032 | 0.006 | 0.0053 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0037 | 0.0079 | 0.0066 |
Echinococcus granulosus | c src tyrosine kinase | 0.0037 | 0.0079 | 0.0074 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0032 | 0.006 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0021 | 0.0015 | 0.0002 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0079 | 0.0066 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.0025 | 0.003 | 0.0017 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0021 | 0.0015 | 0.0362 |
Brugia malayi | Variant SH3 domain containing protein | 0.0032 | 0.006 | 0.037 |
Loa Loa (eye worm) | SRC-1 | 0.0037 | 0.0079 | 0.0519 |
Giardia lamblia | Aurora kinase | 0.0117 | 0.0405 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0405 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0037 | 0.0079 | 0.0064 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0037 | 0.0079 | 0.0064 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0117 | 0.0405 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0327 | 0.1255 | 0.1432 |
Onchocerca volvulus | 0.0327 | 0.1255 | 1 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0032 | 0.006 | 0.0048 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0117 | 0.0405 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | vav2 | 0.0025 | 0.0032 | 0.0019 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0064 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0117 | 0.0405 | 0.0451 |
Schistosoma mansoni | protein kinase | 0.0117 | 0.0405 | 0.0393 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0064 |
Brugia malayi | SRC-1 | 0.0037 | 0.0079 | 0.0519 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0037 | 0.0079 | 0.0074 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0327 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0405 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0117 | 0.0405 | 0.0391 |
Plasmodium vivax | hypothetical protein, conserved | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2488 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.003 | 0.0752 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.0025 | 0.003 | 0.0016 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.2161 | 0.8675 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0079 | 0.0066 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0038 | 0.0083 | 0.0079 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0405 | 0.3148 |
Echinococcus granulosus | aurora kinase A | 0.0117 | 0.0405 | 0.0451 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0032 | 0.006 | 0.0046 |
Brugia malayi | serine/threonine kinase 12 | 0.0117 | 0.0405 | 0.3148 |
Schistosoma mansoni | amine oxidase | 0.0327 | 0.1255 | 0.1244 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0037 | 0.0079 | 0.0064 |
Echinococcus multilocularis | NCK adaptor protein | 0.0032 | 0.006 | 0.0046 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0405 | 0.5 |
Echinococcus multilocularis | 0.0327 | 0.1255 | 0.1242 | |
Entamoeba histolytica | protein kinase , putative | 0.0117 | 0.0405 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0032 | 0.006 | 0.037 |
Schistosoma mansoni | adapter molecule crk | 0.0032 | 0.006 | 0.0048 |
Plasmodium vivax | hypothetical protein, conserved | 0.0327 | 0.1255 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0899 | 0.3568 | 0.4104 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0037 | 0.0079 | 0.0064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0117 | 0.0405 | 0.0393 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0117 | 0.0405 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0079 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0032 | 0.0141 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0405 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0074 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0037 | 0.0079 | 0.0064 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0327 | 0.1255 | 0.1432 |
Trypanosoma brucei | aurora B kinase | 0.0117 | 0.0405 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0327 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.006 | 0.037 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0079 | 0.0066 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0032 | 0.006 | 0.0053 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | amine oxidase | 0.0327 | 0.1255 | 0.1244 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0032 | 0.006 | 0.037 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0327 | 0.1255 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0117 | 0.0405 | 0.3148 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.2161 | 0.8675 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0074 |
Entamoeba histolytica | protein kinase, putative | 0.0117 | 0.0405 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0327 | 0.1255 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0037 | 0.0079 | 0.0064 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2488 | 1 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0327 | 0.1255 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0037 | 0.0079 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0405 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0037 | 0.0079 | 0.0519 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0032 | 0.006 | 0.0048 |
Entamoeba histolytica | protein kinase, putative | 0.0117 | 0.0405 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0037 | 0.0079 | 0.0064 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0327 | 0.1255 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0037 | 0.0079 | 0.0074 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0037 | 0.0079 | 0.0064 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0117 | 0.0405 | 0.3148 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0899 | 0.3568 | 0.3559 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2488 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0405 | 0.3148 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2488 | 1 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0327 | 0.1255 | 0.1242 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0025 | 0.0032 | 0.0141 |
Leishmania major | UDP-galactopyranose mutase | 0.0327 | 0.1255 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0117 | 0.0405 | 1 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.0025 | 0.003 | 0.0018 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0032 | 0.006 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1255 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0883 | 0.3504 | 0.3496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.