Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.3536 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.377 | 0.245 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8068 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 69 uM | Inhibition concentration towards high-affinity ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
IC50 (binding) | = 69 uM | Inhibition concentration towards high-affinity ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 1.2 uM | Binding affinity towards ionotropic glutamate receptor (high-affinity) of rat cortical synaptic membranes by using [3H]-AMPA as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 1.2 uM | Binding affinity towards ionotropic glutamate receptor (high-affinity) of rat cortical synaptic membranes by using [3H]-AMPA as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 3.7 uM | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 3.7 uM | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligand | ChEMBL. | 14695840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.