Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | pteridine reductase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Leishmania infantum | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania braziliensis | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Trypanosoma brucei | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Trypanosoma congolense | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania major | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania mexicana | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Leishmania donovani | pteridine reductase 1 | Get druggable targets OG5_133937 | All targets in OG5_133937 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | pteridine reductase 1 | 288 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0458 | 0.865 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0528 | 1 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0528 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0235 | 0.4304 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0069 | 0.1093 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0069 | 0.1093 | 0.1093 |
Mycobacterium ulcerans | oxidoreductase | 0.0069 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0069 | 0.1093 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.1093 | 1 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0069 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0069 | 0.1093 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0069 | 0.1093 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0458 | 0.865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0069 | 0.1093 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0.1093 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0069 | 0.1093 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0.1093 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0528 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0528 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0069 | 0.1093 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0069 | 0.1093 | 0.1264 |
Mycobacterium ulcerans | dehydrogenase | 0.0069 | 0.1093 | 0.1093 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0069 | 0.1093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0069 | 0.1093 | 0.2504 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0238 | 0.4365 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0069 | 0.1093 | 0.1264 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0069 | 0.1093 | 0.1093 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0069 | 0.1093 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0069 | 0.1093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1093 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0069 | 0.1093 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 4.18 ug ml-1 | Cytotoxicity against human MRC5 cells after 72 hrs by Alamar blue assay | ChEMBL. | 21126022 |
ED50 (functional) | = 10.1 ug ml-1 | Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth by Alamar blue assay | ChEMBL. | 21126022 |
ED50 (functional) | = 22.1 ug ml-1 | Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth by Alamar blue assay | ChEMBL. | 21126022 |
IC50 (binding) | = 93 uM | Inhibition of Leishmania major PTR1 | ChEMBL. | 21126022 |
Inhibition (binding) | Inhibition of human DHFR at 500 uM | ChEMBL. | 21126022 | |
Inhibition (binding) | Inhibition of Leishmania major DHFR at 50 uM | ChEMBL. | 21126022 | |
Inhibition (functional) | = 3.5 % | Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth at 50 ug/ml by Alamar blue assay in presence of pyrimethamine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine DHFR inhibitor | ChEMBL. | 21126022 |
Inhibition (functional) | = 4.1 % | Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth at 50 ug/ml by Alamar blue assay in presence of pyrimethamine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine DHFR inhibitor | ChEMBL. | 21126022 |
Inhibition (functional) | = 4.7 % | Antileishmanial activity against Leishmania mexicana MHOM/BZ/84/BEL46 assessed as growth at 50 ug/ml by Alamar blue assay | ChEMBL. | 21126022 |
Inhibition (functional) | = 7.1 % | Antileishmanial activity against Leishmania major MHOM/SU/73/5-ASKH assessed as growth at 50 ug/ml by Alamar blue assay | ChEMBL. | 21126022 |
Ki (binding) | = 7 uM | Inhibition of Leishmania major PTR1 by Lineweaver-Burk analysis | ChEMBL. | 21126022 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.